305370-87-0

Basic information

• Product Name: 6-amino-4-(3-bromo-phenylamino)-[1.8]naphthyridine-3-carbonitrile
• Synonyms: 6-amino-4-(3-bromo-phenylamino)-[1.8]naphthyridine-3-carbonitrile
• CAS NO: 305370-87-0
• Molecular Weight: 340.182
• Mol File: 305370-87-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-amino-4-(3-bromo-phenylamino)-[1.8]naphthyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-4-(3-bromo-phenylamino)-[1.8]naphthyridine-3-carbonitrile(305370-87-0)
• EPA Substance Registry System: 6-amino-4-(3-bromo-phenylamino)-[1.8]naphthyridine-3-carbonitrile(305370-87-0)

Safety Data

• Hazardous Substances Data: 305370-87-0(Hazardous Substances Data)

Upstream product

• 690223-99-5 4-hydroxy-6-nitro-[1,8]naphthyridine-3-carbonitrile 
• 305370-84-7 4-chloro-6-nitro-[1.8]naphthyridine-3-carbonitrile 
• 42959-38-6 3-carboxy-2-chloro-5-nitro pyridine 

Relevant articles and documents

Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles

The syntheses and EGFR kinase inhibitory activity of a series of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles are described. Both reversible and irreversible binding inhibitors were prepared. These series were compared with each other and with the corresponding 4-anilinoquinoline-3-carbonitriles. Compounds having a 1,7-naphthyridine core structure can retain high potency while those with a 1,8-naphthyridine core are significantly less active. These results are consistent with molecular modeling observations.

SUBSTITUTED 3-CYANO-[1.7], [1.5] AND [1.8] NAPHTHYRIDINE INHIBITORS OF TYROSINE KINASES

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