305375-94-4

Upstream product

• 4930-98-7 pyrid-2-ylhydrazine 
• 456-22-4 4-Fluorobenzoic acid 
• 405-99-2 para-fluorostyrene 
• 110-86-1 pyridine 
• 459-57-4 4-fluorobenzaldehyde 
• 2251-76-5 2-(4-fluorophenyl)-2-oxoacetic acid 
• 274-80-6 [1,2,4]triazolo[4,3-a]pyridine 
• 352-34-1 4-fluoro-1-iodobenzene 
• 176662-02-5 2-(2-(4-fluorobenzylidene)hydrazinyl)pyridine 

Relevant academic research and scientific papers

An environmentally benign and solvent-free synthesis of 3-aryl[1,2,4]triazolo[4,3-a]pyridines and 1-aryl-5-methyl[1,2,4]triazolo[4,3-a] quinolines using phenyliodine bis(trifluoroacetate) or iodobenzene diacetate

A simple, solvent-free and effective method for oxidative cyclization of 2-pyridyl- and 2-quinolylhydrazones with phenyliodine bis(trifluoroacetate) and iodobenzene diacetate to the corresponding 3-aryl[1,2,4]triazolo[4,3-a]pyridines and 1-aryl[1,2,4]tria

TBAI/TBHP-Catalyzed Synthesis of [1,2,4]Triazolo[4,3-a]pyridines and 3,5-Diaryl-1,2,4-oxadiazoles via Oxidative Cleavage of C=C Double Bond

Abstract: A simple and efficient protocol has been described for the synthesis of [1,2,4]triazolo[4,3-a]pyri-dines and 3,5-disubstituted-1,2,4-oxadiazoles by reacting 2-hydrazinylpyridine and benzamidoximes, respec-tively, with styrenes via TBAI/TBHP-mediated oxidative cleavage of C=C bond under ligand- and metal-free conditions.

Method for preparing 3-phenyl-[1,2,4] triazole [4,3-a] pyridine compound without metal catalysis

The invention discloses a method for preparing a 3-phenyl-[1,2,4] triazole [4,3-a] pyridine compound without metal catalysis. The method comprises the following steps: enabling a pyridine compound, sodium azide and a benzaldehyde compound to react suffici

KI-catalyzed oxidative cyclization of α-keto acids and 2-hydrazinopyridines: Efficient one-pot synthesis of 1,2,4-triazolo[4,3-a] pyridines

A one-pot approach to substituted 1,2,4-triazolo[4,3-a]pyridines has been developed that is based on a KI-catalyzed oxidative cyclization of α-keto acids and 2-hydrazinopyridines. This transition-metal-free procedure was highly efficient and shows good economical and environmental advantages.

[1,2,4]-triazol [4,3-a] pyridines compound and synthesis method thereof

The invention discloses a [1,2,4]-triazol [4,3-a] pyridines compound and a synthesis method thereof. The compound has a structure general formula shown as the formula (I), wherein R1 is selected fromaryl and heterocyclic groups; R2 is selected from hydrogen, alkyl, alkoxy, halogen or aryl. According to the synthesis method, alpha-ketonic acid and 2-hydrazinopyridine are used as raw materials; KIis used as a catalyst; Na2CO3 is used as alkali; TBHP is used as an oxidizing agent; 1,4-dioxane is used as a solvent; after a series of serial connection cyclization and decarboxylation aromatization, the [1,2,4]-triazol [4,3-a] pyridines compound is obtained. The [1,2,4]-triazol [4,3-a] pyridines compound is prepared under the condition of no transition metal and has the advantages that the reaction is efficient and fast; the conditions are mild; the substrate is simple and can be easily obtained; the applicability is wide; the reaction time is short; the yield is high, and the like; meanwhile, the post treatment of the reaction is simple and convenient; the harm to experiment operators is reduced; the environment-friendly effect is achieved; the green chemical requirements are met.

1,1′-carbonyldiimidazole (CDI) mediated coupling and cyclization to generate [1,2,4]triazolo[4,3-a]pyridines

An operationally efficient CDI mediated tandem coupling and cyclization reaction to generate [1,2,4]triazolo[4,3-a]pyridines has been reported. The reaction conditions and scope were investigated, and the methodology was demonstrated in batch mode as well

Cu-catalysed direct C-H (hetero)arylation of [1,2,4]triazolo[4,3-a]pyridine to construct deep-blue-emitting luminophores

Cu-catalysed direct C-H (hetero)arylation of [1,2,4]triazolo[4,3-a]pyridine has been accomplished for the first time to streamline the synthesis of 3-aryl-[1,2,4]triazolo[4,3-a]pyridines for screening blue-emitting materials. On this basis, the photophysi

Palladium-catalyzed chemoselective monoarylation of hydrazides for the synthesis of [1,2,4]Triazolo[4,3-a]pyridines

(Chemical Equation Presented) An efficient and convenient method for the synthesis of [1,2,4]triazolo[4,3-a]pyridines was exemplified by the synthesis of 20 analogues bearing a variety of substituents at the 3-position. The methodology involves a palladiu

Palladium-catalyzed coupling of aldehyde-derived hydrazones: Practical synthesis of triazolopyridines and related heterocycles

The palladium-catalyzed intermolecular coupling of aldehyde-derived hydrazones with chloroazines, followed by oxidative cyclization under mild conditions afforded access to a broad variety of bicyclic heterocyclic scaffolds (see scheme) that have potentia