3054-58-8

Usage

Uses

Used in Pharmaceutical Industry:
1-(2,2-diethoxyethyl)pyrimidine-2,4(1H,3H)-dione is used as a key intermediate for the synthesis of various pharmaceuticals for its versatile chemical properties and potential medicinal applications.
Used in Agrochemical Industry:
1-(2,2-diethoxyethyl)pyrimidine-2,4(1H,3H)-dione is used as a building block in the development of agrochemicals, contributing to its synthesis and enhancing the effectiveness of these products.
Used in Anticonvulsant and Antiepileptic Applications:
1-(2,2-diethoxyethyl)pyrimidine-2,4(1H,3H)-dione is used as an active pharmaceutical ingredient for its anticonvulsant and antiepileptic properties, potentially providing treatment options for patients suffering from seizures and epilepsy.
Used in Urinary Excretion Enhancement:
DEEPD is used as a urinary excretion enhancer, potentially aiding in the removal of toxins and waste products from the body, which can be beneficial for various medical conditions.
Used in Mitochondrial Disease Treatment:
1-(2,2-diethoxyethyl)pyrimidine-2,4(1H,3H)-dione is being researched for its potential as a candidate in treating mitochondrial diseases, offering a new avenue for therapeutic intervention in these complex conditions.

Upstream product

• 66-22-8 uracil 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 

Downstream Products

• 3055-23-0 2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetaldehyde 

Relevant academic research and scientific papers

Efficient one-pot, three-component procedure to prepare new α-aminophosphonate and phosphonic acid acyclic nucleosides

An efficient one-pot three-component Kabachnik–Fields reaction of aldehydes (acyclic nucleosides), amines (or amino acid), and triethyl phosphite proceeded for the synthesis of aminophosphonates using natural phosphate coated with iodine (I2@NP) as a catalyst. The novel α-aminophosphonate and phosphonic acid acyclic nucleosides were tested for their anti-HCV and anti-HIV activities. The molecular docking showed that the non-activity of these compounds could be due to the absence of hydrophobic pharmacophores.

Synthesis of polynucleotide analogs containing a polyvinyl alcohol backbone

Water soluble homo-base polynucleotide analogues were synthesized in which polyvinyl alcohol and partially phosphonated polyvinyl alcohol constituted the backbones, onto which were grafted uracil or adenine via 1,3-dioxane spacers formed by acetal formation with the 1,3-diol moieties in PVA. The resulting adenine-PVA polynucleotide analogs exhibited hyperchromic effects, which was not the case for the corresponding uracil compounds. Mixtures of the adenine- and aracil PVA-phosphate polynucleotide analogs in solutions exhibited characteristic S-shaped UV-absorbance vs temperature and melting curves with melting points at approximately 40°C.

Synthesis of novel mimetics of CMP-sialic acid as the inhibitors of sialyltransferases

Novel mimetics of CMP-sialic acid were designed as the inhibitors of sialyltransferases. They were synthesized in a short step from a cytosine carrying β-hydroxy-α-L-amino acid based on the knowledge that nikkomycin, a peptidic derivative of an uracil carrying amino acid, shows a potent inhibitory activity toward N-acetyl-D-glucosaminyltransferases that employ UDP-N-acetyl-D-glucosamine as the donor substrate. The cytosine carrying β-hydroxyl-α-L-amino acid, a key intermediate in our synthetic strategy, was easily prepared by the L-threonine aldolase (LTA) catalyzed reaction.