3054-70-4

Usage

Uses

Used in Pharmaceutical Applications:
(5Z)-2,6-diamino-5-(phenylhydrazono)pyrimidin-4(5H)-one is used as a potential drug candidate for various therapeutic applications due to its unique structural features. Its ability to interact with biological targets and modulate cellular processes makes it a promising compound for the treatment of specific diseases.
Used in Biochemical Research:
In the field of biochemistry, (5Z)-2,6-diamino-5-(phenylhydrazono)pyrimidin-4(5H)-one serves as a valuable research tool. It can be employed to study the interactions between small molecules and biological macromolecules, such as proteins and nucleic acids, providing insights into molecular recognition and binding mechanisms.
Used in Organic Synthesis:
(5Z)-2,6-diamino-5-(phenylhydrazono)pyrimidin-4(5H)-one is used as a building block in organic synthesis for the creation of more complex molecules. Its versatile structure allows for the development of novel compounds with tailored properties and potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Used in Drug Delivery Systems:
Similar to gallotannin, (5Z)-2,6-diamino-5-(phenylhydrazono)pyrimidin-4(5H)-one could be incorporated into drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the compound's efficacy against specific targets, such as cancer cells, could be improved, leading to more effective treatments.

Upstream product

• 113-00-8 guanidine nitrate 
• 62-53-3 aniline 
• 56-06-4 2,6-diaminopyrimidin-4-ol 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of pyrimidine-based derivatives as antitumor agents

In this paper we made a contentious effort to afford heterocyclic compounds with interesting biological activities. The reaction of guanidine with either activated methylene groups, arylhydrazono derivatives, dicyanopropene derivatives, malononitrile dimer or arylhydarazononitrile derivatives afforded diaminopyrimidine derivatives, aryldiazenyl pyrimidine derivatives, fused pyridopyrimidne derivatives and pyrimidopyridazine derivatives respectively. Also the reaction of guanidine with phenylhydrazono carbonyl compounds produced phenyldiazenyl pyrimidine derivatives. The latter products were directed toward the reaction with either acetic anhydride or ethylcyanoacetate to form acetamidopyrimidine derivatives and cyanoacetamidopyrimidine derivatives respectively. The latter products underwent cyclization via reaction with either activated methylene groups or activated methylene carbonyl compounds afforded pyridopyrimidne derivatives. The structures of the newly synthesized compounds were established using IR, 1H NMR, 13C NMR and mass spectrometry and their antitumor activity was investigated. Some of these compounds showed promising inhibitory effects on the three different cell lines.

Studies on the series of azoles and azines. 66. Synthesis, spectra and structure of 5-arylazo- and 5-arylideneamino-2,4,6-triaminopyrimidines and their 6-hydroxy analogs

5-Arylazo and 5-arylideneamino-2,4,6-triaminopyrimidines and their 6-hydroxy analogs were obtained by azo coupling of 2,4,6-triamino- and 2,4-diamino-6-hydroxypyrimidines with aryldiazonium salts, and also by the reaction of benzaldehydes with 2,4,5,6-tetraamino- and 2,4,5-triamino-6-hydroxypyrimidines, respectively. According to spectral data, in solvents with different polarity, these compounds exist preferentially in the triamino- or diaminohydroxy form. The main paths of the mass spectrometric fragmentation of the compounds studied have been determined.