30546-76-0Relevant academic research and scientific papers
REACTION OF ISOCYANIC ACID AND ISOCYANATES WITH DIKETENE. PREPARATION OF 2H-1,3-OXAZINES, 4-PYRONES, AND 2-PYRIDONES
Ozaki, Shoichiro,Nagase, Toshio,Kato, Takazo
, p. 2063 - 2066 (2007/10/02)
Reaction of diketene with isocyanic acid gave the expected product, 2,4-dioxo-6-methyl-3,4-dihydro-2H-1,3-oxazine (2), but with aryl isocyanates gave 3-aryl-2,4-dioxo-6-methyl-3,4-dihydro-2H-1,3-oxazines (3), 3-(arylcarbamoyl)-2,6-dimethyl-4-pyrones (4), and 3-acetyl-1-aryl-4-hydroxy-6-methyl-2-pyridones (5) depending on the reaction conditions.
Process for preparing pyrone-3-carboxamide compounds
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, (2008/06/13)
A new process for preparing a pyrone-3-carboxamide compound of the formula (IV): STR1 wherein R1 is aryl or heterocyclic group optionally substituted, R2 is alkyl, aralkyl or like group, comprising reacting a compound of the formula
Preparation and Antiinflammatory Activity of 2- and 4-Pyridones
Pierce, James Benjamin,Ariyan, Zaven S.,Ovenden, Gaye Stuart
, p. 131 - 136 (2007/10/02)
Several N-alkyl- and N-arylacetoamides have been self-condensed to form pyridones.N-Alkylacetoacetamides give 2-pyridones, while N-arylacetoamides give 4-pyridones.In an attempt to develop nonacidic, nonsteroidal antiinflammatory agents, the pyridones were tested in a carrageenan-induced pedal edema assay in rats.While the 2-pyridones were not active, 9 of 17 4-pyridones tested were active, and one compound (4g) had antiinflammatory efficacy in a dose-response assay (ED50 values).Most compounds were considered nontoxic by determination of approximate LD50 values in mice by a standard multidimensional observational assay.
