3056-00-6

Usage

Uses

Used in Surfactant Production:
3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaoctatetracontan-1-ol is used as a raw material in the production of surfactants due to its long hydrocarbon chain and hydrophilic properties. Surfactants are essential in various industries, including detergents, cleaning agents, and personal care products, for their ability to reduce surface tension and stabilize emulsions.
Used in Emulsifier Production:
In the food and pharmaceutical industries, 3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaoctatetracontan-1-ol is used as a component in the formulation of emulsifiers. Its amphiphilic nature allows it to act as a stabilizer, preventing the separation of immiscible liquids and improving the texture and consistency of products.
Used in Cosmetics and Personal Care Products:
3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaoctatetracontan-1-ol is used as an ingredient in cosmetics and personal care products, such as creams, lotions, and shampoos. Its emollient properties help to moisturize and soften the skin, while its compatibility with other ingredients makes it a versatile component in various formulations.
Used in Lubricants and Greases:
Due to its long hydrocarbon chain and low polarity, 3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaoctatetracontan-1-ol is used in the formulation of lubricants and greases for various applications, including automotive, industrial machinery, and metalworking. It provides excellent lubrication and reduces friction between moving parts, extending the life of equipment and reducing wear.
Used in Textile Industry:
In the textile industry, 3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaoctatetracontan-1-ol is used as a softening agent and emulsifier in the production of textiles. It helps to improve the softness, flexibility, and handle of fabrics, making them more comfortable to wear and easier to process during manufacturing.
Used in Agriculture:
3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaoctatetracontan-1-ol is used in the agricultural sector as an adjuvant in pesticide formulations. Its surfactant properties help to improve the spreading, wetting, and absorption of pesticides on plant surfaces, enhancing their effectiveness and reducing the amount of chemical needed.

InChI:InChI=1/C36H74O13/c1-2-3-4-5-6-7-8-9-10-11-13-38-15-17-40-19-21-42-23-25-44-27-29-46-31-33-48-35-36-49-34-32-47-30-28-45-26-24-43-22-20-41-18-16-39-14-12-37/h37H,2-36H2,1H3

Upstream product

• 2615-15-8 pentaethylene glycol 
• 17464-54-9 1-{2-[2-(2-{2-[2-(2-chloro-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-dodecane 
• 3055-94-5 2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethanol 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 3055-99-0 polidocanol 
• 3055-96-7 Hexaethylene glycol monododecyl ether 

Relevant academic research and scientific papers

Structure of monolayers of monododecyl dodecaethylene glycol at the air-water interface studied by neutron reflection

The structure of a monododecyl dodecaethylene glycol monolayer adsorbed at the air-water interface was determined at its critical micellar concentration by neutron reflection with deuterium labeling. The optical matrix method and the kinematic approximation gave structures identical within the limitations of the models used. In the optical matrix method, the monolayer was divided into the alkyl chain layer and a layer of the ethoxylated head, a fraction of the alkyl chain and water. Significant intermixing of the alkyl chain and ethoxylated headgroup was needed to account for the observed reflectivities. The distance between the centers of the alkyl chain and solvent distributions were found by the kinematic method.

Application of Monodisperse PEGs in Pharmaceutics: Monodisperse Polidocanols

Polydisperse PEGs are ubiquitously used in pharmaceutical industry and biomedical research. However, the monodispersity in PEGs may play a role in the development of safe and effective PEGylated small molecular drugs. Here, to avoid the polydispersity in polidocanol, the active ingredient in a clinically used drug, a macrocyclic sulfate-based strategy for the efficient and scalable synthesis of monodisperse polidocanols, their sulfates, and their methylated derivatives, was developed. TLC and HPLC analysis indicated a complex mixture in regular polidocanol and high purities in monodisperse polidocanols and their derivatives. Assay on HUVEC, L929, and HePG2 cells showed that monodisperse polidocanols have much higher cytotoxicity and safety than that of regular polidocanol. It was found that the monodispersity of PEGs in polidocanols is crucial for achieving the optimal therapeutic results. Therefore, based on this case study, it would be beneficial to optimize PEGylated small molecular drugs with monodisperse PEGs in pharmaceutical research and development.

Combinatorial synthesis of PEG oligomer libraries

A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.