30563-16-7

Usage

Uses

Used in Organic Synthesis:
[R,(-)]-1-O,2-O-Dipalmitoyl-3-O-trityl-D-glycerol is used as a building block for the preparation of glycerol-based lipids and phospholipids, which are essential components of cell membranes and have various biological functions.
Used in Drug Delivery Systems:
[R,(-)]-1-O,2-O-Dipalmitoyl-3-O-trityl-D-glycerol is used as a component in drug delivery systems for its potential to enhance the delivery, bioavailability, and therapeutic outcomes of various drugs.
Used in Lipidomics:
[R,(-)]-1-O,2-O-Dipalmitoyl-3-O-trityl-D-glycerol is used as a research tool in lipidomics, the study of lipids and their interactions with other biological systems, to better understand the roles of lipids in cellular processes and diseases.
Used in Lipid-based Nanotechnology:
[R,(-)]-1-O,2-O-Dipalmitoyl-3-O-trityl-D-glycerol is used in lipid-based nanotechnology for the development of novel nanostructures and materials with potential applications in drug delivery, diagnostics, and therapeutics.
Used in Pharmaceutical Industry:
[R,(-)]-1-O,2-O-Dipalmitoyl-3-O-trityl-D-glycerol is used as a starting material for the synthesis of various pharmaceutical compounds, particularly those targeting lipid-related diseases and conditions.
Used in Cosmetics Industry:
[R,(-)]-1-O,2-O-Dipalmitoyl-3-O-trityl-D-glycerol is used as an ingredient in the development of cosmetic products, leveraging its properties to improve skin hydration, texture, and overall health.
It is important to handle and use [R,(-)]-1-O,2-O-Dipalmitoyl-3-O-trityl-D-glycerol with proper safety precautions, as it can be hazardous if mishandled or exposed to certain conditions.

Upstream product

• 17327-05-8 (S)-3-(trityloxy)propane-1,2-diol 
• 112-67-4 n-hexadecanoyl chloride 
• 16814-88-3 methyl (2R)-2-methoxy-3-(triphenylmethoxy)propanoate 
• 19670-51-0 (R)-2,3-dihydroxypropyl n-hexadecanoate 
• 57416-03-2 (R)-2,2-dimethyl-1,3-dioxolan-4-ylmethyl n-hexadecanoate 
• 30563-15-6 1-O-trityl-3-O-palmitoyl-sn-glycerol 

Downstream Products

• 115290-75-0 C₄₄H₇₉N₃O₁₅P₂^(2-)*2Na⁽¹⁺⁾ 
• 58560-71-7 dipalmitoylphosphatidic acid 
• 6076-30-8 1,2-di-O-palmitoyl-sn-glycerol 

Relevant academic research and scientific papers

A new approach to the stereospecific synthesis of phospholipids. The use of L-glyceric acid for the preparation of diacylglycerols, phosphatidylcholines, and related derivatives

A new stereospecific synthesis of phospholipid derivatives of 1,2- diacyl-sn-glycerols is reported. The synthesis is based on (1) the use of L- glyceric acid as the stereocenter for construction of the optically active phospholipid molecule, (2) preparation of 3-triphenylmethyl-sn-glycerol as the key intermediate for sequential introduction of the primary and secondary acyl functions leading to the chiral diglycerides, and (3) elaboration of the sn-3-phosphodiester headgroup via phosphorylation using 2-chloro-2-oxo-1,3,2- dioxaphospholane, followed by ring opening of the five-membered phosphorus heterocycle with trimethylamine, ammonia, as well as oxygen and sulfur nucleophiles. The sequence has been shown to be suitable for the preparation of both symmetric and mixed-chain diacylglycerols with saturated and unsaturated acyl substituents. Phospholipid headgroups including phosphocholine, phosphoethanolamine, phosphoethanol, and phosphoethylthioacetate functions have been prepared. Application of the method to the synthesis of functionalized phosphatidylcholines has also been demonstrated by incorporating spectroscopically active spin-labeled and fluorescent reporter groups via postsynthetic derivatization of chain terminal ω-aminoalkyl functions of the acyl substituents of the compounds. The synthetic methods developed have a great deal of flexibility, providing convenient routes to a wide range of structurally variable phospholipids for physicochemical, enzymological, and cell-biological studies.

Nucleoside conjugates. 10. Synthesis and antitumor activity of 1-β-D-arabinofuranosylcytosine 5'-diphosphate-1,2-dipalmitins

Three 1-β-D-arabinofuranosylcytosine 5'-diphosphate-1,2-dipalmitins from L-, D- and DL-α-dipalmitoylphosphatidic acids have been synthesized and their antitumor activity against two ara-C2 resistant L1210 lymphoid leukemia sublines in mice were evaluated. These new prodrugs of ara-C include ara-CDP-L-dipalmitin (1), ara-CDP-D-dipalmitin (2), and ara-CDP-DL-dipalmitin (3). The L and DL isomers produced significant increase in life span (>400%) and four to five long-term survivors (>45 days) out of six animals bearing ip implanted partially ara-C resistant L1210 subline [L1210/ara-C (I)], while the D isomer displayed a marginal activity (ILS 100-121%). In contrast, the L isomer was completely ineffective against deoxycytidine kinase deficient ara-C resistant L1210 subline [L1210/ara-C (II)]. However, the results demonstrate that the L and DL isomers of ara-CDP-dipalmitin are promising new prodrugs of ara-C with improved efficacy.