30575-38-3Relevant academic research and scientific papers
TRIAZOLE DERIVATIVES AS TANKYRASE INHIBITORS
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, (2018/07/29)
The present invention relates to compounds of formula (I'), tautomers, stereoisomers, and pharmaceutically acceptable salts thereof, to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy (I') (wherein: Z represents an optionally substituted, 5- or 6-membered unsaturated heterocyclic group comprising at least one nitrogen atom; L represents a 4-, 5- or 6-membered cycloalkyl group, preferably a cyclobutyl group; each R1 independently represents F, CI, Br, I, C1-3 alkyl, C1-3 haloalkyl (e.g. -CF3), -CN, -OH or -NO2, preferably F, CI, Br or 1, e.g. CI or F; each R2independently represents F, CI, Br, I, C1-3 alkyl, -CN, -OH or -NO2, preferably F, CI, Br, I or -CN, e.g. F or -CN; X represents -NR3- or -0-; R3 represents H or a C1-3 alkyl group (e.g. methyl); n is an integer from 0 to 5, preferably 0 to 3, more preferably 0, 1 or 2, e.g 1; and m is an integer from 0 to 5, preferably 0 to 3, more preferably 0, 1 or 2, e.g. 0 or 1). These compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the WNT pathway and increased presence of nuclear β-catenin. For example, these may be used in preventing and/or retarding proliferation of tumor cells and metastasis, for example carcinomas such as colon carcinomas.
Synthesis and structure of nickel(II) thiocarboxamide complexes: Effect of ligand substitutions on DNA/protein binding, antioxidant and cytotoxicity
Kumar, Ramasamy Raj,Mohamed Subarkhan, Mohamed Kasim,Ramesh, Rengan
, p. 46760 - 46773 (2015/06/16)
Four low spin d8 nickel(ii) square planar complexes with general formula [Ni(L)2] (where L = monobasic N, S bidentate thiocarboxamides) have been synthesized from the reaction of Ni(OAc)2·4H2O with 2 equivalent
Cationic arene ruthenium(II) complexes bearing N, S chelating thiocarboxamides: Synthesis, structure, characterization and catalytic oxidation of alcohols
Raja, M. Ulaganatha,Ramesh
experimental part, p. 5 - 11 (2012/03/10)
A series of conformationally rigid half-sandwich diamagnetic cationic organoruthenium(II) complexes with the general formula [Ru(η6-p- cymene)(AsPh3)(L)] [where, L = pyridine-2-thiocarboxamide ligand] have been synthesized from the reaction of [Ru(η6-p-cymene) Cl2]2 with bidentate thiocarboxamide ligands and AsPh 3 in methanol in 1:2 M ratio. All the arene ruthenium(II) complexes were fully characterized by FT-IR, 1H NMR, and UV-Vis spectroscopy as well as elemental analysis. The solid-state structure of one of the complexes [Ru(η6-p-cymene)(AsPh3)(L4)]BPh4 has been determined by single crystal X-ray crystallography. Further, the catalytic efficiency of one of the complexes (4) has been investigated in the case of oxidation of primary and secondary alcohols into their corresponding aldehydes and ketones in the presence of N- methylmorpholine-N-oxide.
Palladium(ii) thiocarboxamide complexes: Synthesis, characterisation and application to catalytic Suzuki coupling reactions
Sindhuja, Elangovan,Ramesh, Rengan,Liu, Yu
body text, p. 5351 - 5361 (2012/05/20)
A simple route to synthesise palladium(ii) complexes from the reaction of N-substituted pyridine-2-thiocarboxamide ligands and PdCl2(PPh 3)2 has been developed. The new complexes are very soluble in common solvents and have been fully characterised (elemental analysis, FT-IR, 1H, 31P, 13C-NMR), including an X-ray diffraction analysis. The molecular structures of all the complexes were determined and reveal the presence of square planar geometry around Pd with little distortion. The complexes were tested in the Suzuki coupling of electronically deactivated aryl and heteroaryl bromides and were found to have much greater activity, without using any promoting additives or phase transfer agent under aerobic conditions. Higher reaction rates are obtained by varying R substituents on the aromatic ring of pyridine-2-thiocarboxamide. The effect of other variables on the cross-coupling reaction, such as temperature, solvent and base, is also reported.
