305811-35-2Relevant academic research and scientific papers
Imidazoline derivatives as alpha-1A adrenoceptor ligands
-
Page/Page column 32, (2010/02/11)
Compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed. Such compounds are useful in the treatment of Alpha-1A mediated diseases or conditions such as urinary incontinence.
2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series.
Navas 3rd., Frank,Bishop, Michael J,Garrison, Deanna T,Hodson, Stephen J,Speake, Jason D,Bigham, Eric C,Drewry, David H,Saussy, David L,Liacos, James H,Irving, Paul E,Gobel, M Jeffrey
, p. 575 - 579 (2007/10/03)
A series of 2'-heteroaryl and 2'-oxime anilinomethylimidazolines was prepared and evaluated in in vitro functional assays for cloned human alpha1A, alpha1B, and alpha1D receptor subtypes. Potent and selective alpha1A agonists have been identified in these series.
