305811-46-5

Usage

Pyrazole derivative

A class of organic compounds containing a five-membered heterocyclic ring with two nitrogen atoms at opposite positions.

Methyl group

A CH3 functional group attached to the pyrazole ring, contributing to the compound's structure and chemical properties.

Nitrophenyl group

A functional group containing a nitro group (-NO2) attached to a phenyl ring (a six-membered carbon ring with alternating single and double bonds), which is present in the molecule and influences its reactivity and properties.

Unique chemical properties

The presence of the methyl and nitrophenyl groups in the molecule gives 1-methyl-5-(2-nitrophenyl)-1H-pyrazole its distinct chemical behavior and reactivity.

Potential applications

1-methyl-5-(2-nitrophenyl)-1H-pyrazole may have uses in pharmaceuticals, agrochemicals, and materials science due to its structural features and potential reactivity.

Biological activity

1-methyl-5-(2-nitrophenyl)-1H-pyrazole may exhibit biological activity, which could make it a potential drug candidate for various therapeutic applications.

Upstream product

• 60-34-4 methylhydrazine 
• 153813-81-1 (E)-3-(N,N-dimethylamino)-1-(2-nitrophenyl)-2-propen-1-one 
• 74-88-4 methyl iodide 
• 87488-61-7 3-(dimethylamino)-1-(2-nitrophenyl)prop-2-en-1-one 
• 577-59-3 2-acetylnitrobenzene 

Relevant academic research and scientific papers

A simple synthesis of 5-(2-Aminophenyl)-1H-pyrazoles

A four-step synthesis of 1-substituted 5-(2-aminophenyl)-1H-pyrazoles 5 as a novel type of histamine analogs and versatile building blocks for further transformations was developed. The synthesis starts from commercially available 2-nitroacetophenone (12), which is converted into the enamino ketone 13 as the key intermediate. Cyclization of the key intermediate 13 with monosubstituted hydrazines 14a-14l afforded the 5-(2-nitrophenyl)-1H-pyrazoles 17a-17l. Finally, catalytic hydrogenation of the nitro compounds 17a, 17c-17e, and 17g-17j furnished the title compounds 5a, 5c-5e, and 5g-5j, respectively, in good yields. As demonstrated by some further transformations, additional functionalization of compounds 17 and 5 is feasible, either by electrophilic substitution at C(4) of the pyrazole ring, or at the NH2 group. Copyright

Pyrazole compounds

Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a compound of the present invention, alone or in combination wit

Imidazoline derivatives as alpha-1A adrenoceptor ligands

Compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed. Such compounds are useful in the treatment of Alpha-1A mediated diseases or conditions such as urinary incontinence.

2-(Anilinomethyl)imidazolines as α1 adrenergic receptor agonists: α1a subtype selective 2′-heteroaryl compounds

The structure-activity relationship of 2′-pyrrole, pyrazole and triazole substituted 2-(anilinomethyl)imidazolines as α1 adrenergic agonists was investigated. The size and orientation of substituents, as well as the position of the heteroatoms, were found to have a profound effect on the potency and selectivity of the molecules. Potent α1A subtype selective agonists have been identified.