305818-77-3

Upstream product

• 2916-68-9 2-(Trimethylsilyl)ethanol 
• 619-58-9 4-iodobenzoic acid 

Downstream Products

• 860402-21-7 4-trimethylsilanylethynyl-benzoic acid 2-trimethylsilanyl-ethyl ester 
• 812699-15-3 (CH₂BH₃P(C₆H₄COOCH₂CH₂Si(CH₃)3)2)2 
• 1314582-97-2 2,2',2'',2'''-{{(2S)-3-{{4'-{[2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-2-deoxy-β-D-glucopyranosyl]carbamoyl}biphenyl-4-yl}amino}-3-oxopropane-1,2-diyl}dinitrilo}tetraacetic acid 
• 1314582-99-4 tetra(tert-butyl) 2,2',2'',2'''-{{(2S)-3-{{4'-{[2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-2-deoxy-β-D-glucopyranosyl]carbamoyl}biphenyl-4-yl}amino}-3-oxopropane-1,2-diyl}dinitrilo}tetraacetate 

Relevant academic research and scientific papers

Lanthanide-chelating carbohydrate conjugates are useful tools to characterize carbohydrate conformation in solution and sensitive sensors to detect carbohydrate-protein interactions

The increasing interest in the functional versatility of glycan epitopes in cellular glycoconjugates calls for developing sensitive methods to define carbohydrate conformation in solution and to characterize protein-carbohydrate interactions. Measurements of pseudocontact shifts in the presence of a paramagnetic cation can provide such information. In this work, the energetically privileged conformation of a disaccharide (lactose as test case) was experimentally inferred by using a synthetic carbohydrate conjugate bearing a lanthanide binding tag. In addition, the binding of lactose to a biomedically relevant receptor (the human adhesion/growth-regulatory lectin galectin-3) and its consequences in structural terms were defined, using Dy3+, Tb3+, and Tm3+. The described approach, complementing the previously tested protein tagging as a way to exploit paramagnetism, enables to detect binding, even weak interactions, and to characterize in detail topological aspects useful for physiological ligands and mimetics in drug design.

A rigid lanthanide binding tag for NMR structural analysis of carbohydrates

The first synthesis of a carbohydrate molecule covalently bound to a rigid lanthanide binding tag is reported. This derivative has been designed as a new tool to provide long-range restraints for structural elucidation and molecular recognition studies of carbohydrates, thus extending the methodology already developed for proteins.

A facile synthetic route to monodisperse asymmetrical oligo(phenylene- ethynylene)s

Monodisperse asymmetrical oligo(phenylene-ethynylene)s were synthesized iteratively by combining the selective deprotection and the Sonogashira coupling. Trimethylsilylethyl ester (TSE) and trimethylsilyl (TMS) were used as protecting groups for carboxyl