305839-17-2Relevant academic research and scientific papers
Palladium supported on silica-chitosan hybrid material (Pd-CS@SiO2) for Suzuki-Miyaura and Mizoroki-Heck cross-coupling reactions
Jadhav, Sanjay,Kumbhar, Arjun,Salunkhe, Rajashri
, p. 339 - 345 (2015)
Palladium supported on silica-chitosan hybrid material was prepared and characterized using thermogravimetric and differential thermogravimetric analyses, scanning electron microscopy, and Fourier transform infrared, energy-dispersive X-ray and X-ray photoelectron spectroscopies. The prepared Pd-CS@SiO2 catalyst (1 mol%) was used for the Suzuki-Miyaura cross-coupling reaction of various aryl halides and arylboronic acids in 95% ethanol at 80 °C and the Mizoroki-Heck reaction in dimethylformamide at 110 °C using K2CO3 as a base. The developed catalyst is well suitable for the 3R approach (recoverable, robust, recyclable) for cross-coupling reactions without appreciable loss of its activity.
Mizoroki–Heck cross-coupling reactions using palladium immobilized on DABCO-functionalized silica
Jadhav, Sanjay,Patil, Seema,Kumbhar, Arjun,Kamble, Santosh,Salunkhe, Rajashri
, p. 507 - 514 (2019/04/25)
A heterogeneous palladium catalyst supported on silica modified by DABCO has been prepared by post-synthetic modification of silica gel. This heterogeneous catalytic system exhibits high activity and stability in the Mizoroki–Heck cross-coupling reaction of various aryl halides with olefins. The reaction proceeds efficiently under efficiently under mild mild reaction conditions and high yield, with the formation of E-isomers selectively. Moreover, we successfully established a gram-scale synthesis, and the catalyst was reused for up to ten catalytic cycles.
An efficient palladium catalyzed Mizoroki-Heck cross-coupling in water
Jadhav, Sanjay N.,Rode, Chandrashekhar V.
supporting information, p. 5958 - 5970 (2017/12/26)
The homogeneous Pd-catalysed Mizoroki-Heck coupling reaction was successfully performed in water in the absence of any additives under aerobic conditions. The various key reaction parameters that affect the yield of the desired cross-coupling product were optimized. The Pd(PPh3)4/Et3N/H2O/98 °C catalyst system was found to be highly active (TOF = 12 to 14 h-1) towards achieving excellent yield of the Mizoroki-Heck coupling products for a wide range of electron-withdrawing as well as electron-donating aryl bromides and chlorides in the shortest reaction time. Pd(PPh3)4 catalyst deactivation during the Mizoroki-Heck coupling reaction was investigated and to evolve a strategy for achieving ten times Pd-metal recyclability without appreciable loss of its activity. Thus, the proposed mechanism provides access to a variety of olefins in aqueous medium, making this protocol eco-friendly.
Synthesis of photoaffinity derivatives of adenophostin A
De Kort, Martin,Luijendijk, Jaco,Van Der Marel, Gijs A.,Van Boom, Jacques H.
, p. 3085 - 3092 (2007/10/03)
Photoaffinity derivatives 7 and 8 of adenophostin A, modified at the 5'- and 1'-positions, were prepared by a chemoselective reaction of the aminophostins 15 and 30 with N-succini-midyl p-benzoyl-2,3-dihydrocinnamate (p-benzoyldihydrocinnamoyl-N-hydroxysu
