305860-85-9

Basic information

• Product Name: 1-[[3-(4-methoxyphenyl)-5-isoxazolyl]methyl]-1H-1,2,3-benzotriazole
• Synonyms: 1-[[3-(4-methoxyphenyl)-5-isoxazolyl]methyl]-1H-1,2,3-benzotriazole
• CAS NO: 305860-85-9
• Molecular Weight: 306.324
• Mol File: 305860-85-9.mol

Chemical Properties

• CAS DataBase Reference: 1-[[3-(4-methoxyphenyl)-5-isoxazolyl]methyl]-1H-1,2,3-benzotriazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[[3-(4-methoxyphenyl)-5-isoxazolyl]methyl]-1H-1,2,3-benzotriazole(305860-85-9)
• EPA Substance Registry System: 1-[[3-(4-methoxyphenyl)-5-isoxazolyl]methyl]-1H-1,2,3-benzotriazole(305860-85-9)

Safety Data

• Hazardous Substances Data: 305860-85-9(Hazardous Substances Data)

Upstream product

• 74903-79-0 N-hydroxy-4-methoxybenzenecarboximidoyl chloride 
• 142321-23-1 1-(1H-benzotriazol-1-yl)prop-2-yne 
• 95-14-7 1,2,3-Benzotriazole 
• 3717-21-3 (E)-4-methoxybenzaldoxime 

Downstream Products

• 333381-98-9 1-[1-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-phenylethyl]-1H-1,2,3-benzotriazole 

Relevant articles and documents

Efficient synthesis of 3,5-functionalized isoxazoles and isoxazolines via 1,3-dipolar cycloaddition reactions of 1-propargyl- and 1-allylbenzotriazoles

3-Aryl-5-(benzotriazol-1-ylmethyl)- 10a-f and 3-p-methoxyphenyl-5-(α-benzotriazol-1-yl-α-ethoxymethyl)-isoxazol e (13) were prepared in high yields by 1,3-dipolar cycloadditions of 1-propargylbenzotriazole (5) and (α-ethoxypropargyl)benzotriazole (8), respectively, with nitrile oxides 3a-f (prepared in situ from benzohydroximoyl chlorides 2a-f). The benzotriazol-1-ylmethyl moiety was further elaborated by sequential lithiation and reaction with aldehydes, alkyl halides and Michael acceptors. Similar 1,3-cycloadditions using 1-allylbenzotriazole (6) and 1-(α-ethoxyallyl)benzotriazole (7) afforded 3,5-substituted isoxazolines 11b,f and 12 in excellent yields.