30612-17-0

Upstream product

• 41570-02-9 2-(2,3-dihydrobenzo[d]thiazol-2-yl)-4-methoxyphenol 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 1141-88-4 2-Aminophenyl disulfide 
• 2612-02-4 5-methoxysalicylic acid 
• 137-07-5 2-amino-benzenethiol 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 

Downstream Products

• 24978-47-0 2-(1,3-benzothiazol-2-yl)-1,4-benzenediol 

Relevant academic research and scientific papers

In situ generation of photoactivatable aggregation-induced emission probes for organelle-specific imaging

Photoactivatable fluorescent probes are ideal tools for organelle study with a significant advantage of high spatiotemporal resolution. However, conventional photo-caged fluorophores for organelle-specific imaging suffer from several drawbacks, such as aggregation-caused quenching (ACQ), instability under ambient light, low photoactivation efficiency, and toxic photo-cleavage byproducts. Herein, we propose a strategy for in situ generation of photoactivatable aggregation-induced emission (AIE) probes of 2-(2-hydroxyphenyl)-benzothiazolines from easily available disulfide and thiol substrates through tandem S-S bond reduction and intramolecular cyclization reaction. Because the photoactivatable AIE probes can be in situ generated in a quantitative yield, they can be directly used for bio-imaging without complicated separation steps. Under both one- and NIR two-photon irradiation, excellent spatiotemporal resolution and high photoactivation efficiency were achieved for specific imaging of lipid droplets and lysosomes, respectively. Based on their in situ generation and adjustable organelle-targeting ability, the photoactivatable AIE probes could become an easy-to-use imaging tool in the study of the biological functions of organelles.

A turn-on fluorescent sensor for selective detection of hydrazine and its application in Arabidopsis thaliana

In this work, a primary method was constructed for detecting hydrazine in plant, thus accomplished the closed-loop monitoring of hydrazine circulation within manufacture, environment, plants, animals and human. From a series of sensors, QYL-1 was selected

Imine-Amine Tautomerism vs Keto-Enol Tautomerism: Acceptor Basicity Dominates over Acceptor Electronegativity in the ESIPT Process through a Six-Membered Intramolecular H-Bonded Network

Photophysical properties of a synthesized asymmetric two-way proton transfer molecule 3-(benzo[d]thiazol-2-yl)-2-hydroxy-5-methoxybenzaldehyde (BTHMB) were studied in detail. BTHMB could undergo excited-state intramolecular proton transfer (ESIPT) involvi

Glutathione-responsive prodrug conjugates for image-guided combination in cancer therapy

Theranostic prodrug was highly desirable for precise diagnosis and anti-cancer therapy to decrease side effects. However, it is difficult to conjugate chemo-drug and molecular probe for combined therapy due to the complex pharmacokinetics of different molecules. Here, a novel anticancer theranostic prodrug (BTMP-SS-PTX) had been designed and synthesized by conjugating paclitaxel (PTX) with 2-(benzo[d]thiazol-2-yl)-4-methoxyphenol (BTMP) through a disulphide (-S-S-) linkage, which was redox-sensitive to the high concentration of glutathione in tumors. Upon activation with glutathione in weakly acid media, the BTMP-SS-PTX can be dissociated to release free PTX and visible BTMP, which realized the visual tracking of free drug. The cytotoxicity study demonstrated that soluble prodrug BTMP-SS-PTX displayed more outstanding anticancer activity in HepG2, MCF-7 and HeLa cells, lower toxicity to non-cancer cells (293 T) than free drugs. Furthermore, BTMP-SS-PTX was still able to induce apoptosis of HeLa cells and significantly inhibited tumor growth in HeLa-xenograft mouse model. On the basis of these findings, BTMP-SS-PTX could play a potential role in cancer diagnosis and therapy.

New Boron(III) Blue Emitters for All-Solution Processed OLEDs: Molecular Design Assisted by Theoretical Modeling

Luminescent boron(III) complexes have recently been employed as emitters in organic light-emitting diodes (OLEDs) with reasonable success. They are easy to prepare and sufficiently stable to be used in such devices, being of great interest as a simple mol

Photoactivated aggregation-inducing luminescent probe having in-situ generation capability and preparation and application thereof

The invention belongs to the technical field of biological imaging, and discloses a photoactivated aggregation-inducing luminescent probe having in-situ generation capability and a preparation and application thereof. The preparation method comprises the following steps: reacting a bis(2-(2--hydroxybenzylidene)amino)aryldisulfide compound with a thiol to obtain the photoactivated aggregation-inducing luminescent probe, which has the structural formula III. The photoactivated aggregation-inducing luminescent probe is gathered in a specific organelle to produce a 2-(2-hydroxyphenyl)benzothiazolecompound having aggregation-inducing luminescent properties by photooxidation. The photoactivated aggregation-inducing luminescent probe having in-situ generation capability can effectively overcomethe defects of aggregation-induced quenching of traditional fluorescent dyes, and realize the organelle-targeting specific photo-activated fluorescence imaging in living cells, and has the advantagesof easy preparation, long-term storage, high light activation efficiency, large Stokes displacement, and strong ability to enter the cells.

A ratiometric fluorescent chemosensor for the detection of cysteine in aqueous solution at neutral pH

A ratiometric fluorescent chemosensor 2-(2′-hydroxy-3′-formyl-5′-methoxyphenyl)benzothiazole (1) was developed for the detection of cysteine (Cys). In aqueous solution at neutral pH, 1 exhibited a ratiometric fluorescent response to Cys with a remarkable red-to-green shift in the emission wavelength. This fluorescence change was attributed to the cyclization reaction between the formyl group in 1 and the amino and sulfhydryl group in Cys in a stoichiometry of 1: 1 according to the proposed mechanism. At neutral pH, 1 displayed a significant fluorescence ratio signal enhancement with the addition of Cys. Furthermore, 1 showed good selectivity toward Cys. The detection limit and linear range were 5.6 and 0–100?μmol/L, respectively, which demonstrated that 1 could recognize relatively low concentrations of Cys and is a good candidate for applications in detecting Cys.

PH (potential of hydrogen) fluorescence probe on basis of 2-(2'-hydroxycyclohexyl phenyl ketone) benzothiazole derivatives, method for preparing pH fluorescence probe and application thereof

The invention discloses a pH (potential of hydrogen) fluorescence probe on the basis of 2-(2'-hydroxycyclohexyl phenyl ketone) benzothiazole derivatives, a method for preparing the pH fluorescence probe and application thereof. R groups are directly connected with 2-(2'-hydroxycyclohexyl phenyl ketone) benzothiazole parent bodies or are connected with the 2-(2'-hydroxycyclohexyl phenyl ketone) benzothiazole parent bodies by benzene rings to obtain the pH fluorescence probe on the basis of the 2-(2'-hydroxycyclohexyl phenyl ketone) benzothiazole derivatives; the R groups are pyridyl, thienyl, quinolyl, furyl, pyrimidine heterocycle aromatic groups, hydroxyl, methyl, methoxy, carboxyl or sulfonyl. The pH fluorescence probe, the method and the application have the advantages that ratiometric fluorescence response can be carried out, wavelengths of two fluorescence channels are greatly different from one another, accordingly, the fluorescence channels are free of interference on one another during detection, and fluorescence signalization can be easily observed by naked eyes; the pH fluorescence probe is high in Stokes shift, and accordingly influence on detection due to excitation light sources can be effectively prevented; the pH fluorescence probe is high in pH response sensitivity, the titration end point of the pH fluorescence probe can be within the ranges from weakly acidic ranges to weakly alkaline ranges under the control, and the pH fluorescence probe is quite suitable for detecting subtle pH change of life samples and food samples; the pH fluorescence probe is high in anti-interference capacity.

2-(Benzothiazol-2-yl)-phenyl-β-d-galactopyranoside derivatives as fluorescent pigment dyeing substrates and their application for the assay of β-d-galactosidase activities

2-(Benzothiazol-2-yl)-phenyl-β-d-galactopyranoside derivatives were synthesized as novel artificial fluorescent pigment dyeing substrates for β-d-galactosidase. The substrates, which exhibited non-fluorescence or weak fluorescence in solution phase, were

Solid-state Fluorescent Photophysics of Some 2-Substituted Benzothiazoles

The solid-state fluorescence properties of a series of benzothiazoles with phenyl, napthalene, and coumarin moieties substituted at the 2-position have been investigated.The necessity for a 2'-OH substituent for fluorescence has been confirmed and the effects of further substitution in the 2-phenyl ring are reported.