41570-02-9

Upstream product

• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 137-07-5 2-amino-benzenethiol 
• 1141-88-4 2-Aminophenyl disulfide 
• 139954-11-3 N,N'-[1,1'-dithiobis(phenyl)]bis(5-methoxysalicylaldimine) 

Downstream Products

• 105129-60-0 3-acetyl-2-(2-hydroxy-5-methoxyphenyl)benzothiazoline 
• 112946-94-8 2-(2-Hydroxy-5-methoxy-phenyl)-benzothiazole-3-carbaldehyde 
• 93264-85-8 1-{2-[2-(3-Chloro-propoxy)-5-methoxy-phenyl]-benzothiazol-3-yl}-ethanone 
• 112947-01-0 2-[2-(5-Bromo-pentyloxy)-5-methoxy-phenyl]-benzothiazole-3-carbaldehyde 
• 93265-04-4 3-acetyl-2-[2-(4-chlorobutoxy)-5-methoxyphenyl]benzothiazoline 
• 99320-58-8 3-acetyl-2-<2-(4-bromobutoxy)-5-methoxyphenyl>benzothiazoline 
• 86136-53-0 1-{2-[2-(5-Bromo-pentyloxy)-5-methoxy-phenyl]-benzothiazol-3-yl}-ethanone 
• 112946-78-8 1-{2-[2-(4-Amino-butoxy)-5-methoxy-phenyl]-benzothiazol-3-yl}-ethanone 
• 86135-21-9 1-{2-[2-(3-Dimethylamino-propoxy)-5-methoxy-phenyl]-benzothiazol-3-yl}-ethanone 
• 112946-80-2 1-{2-[5-Methoxy-2-(4-methylamino-butoxy)-phenyl]-benzothiazol-3-yl}-ethanone 
• 86135-23-1 1-(2-{2-[3-(Cyclohexyl-methyl-amino)-propoxy]-5-methoxy-phenyl}-benzothiazol-3-yl)-ethanone 
• 112946-55-1 2-{2-[5-(Cyclohexyl-methyl-amino)-pentyloxy]-5-methoxy-phenyl}-benzothiazole-3-carbaldehyde 
• 86135-25-3 1-(2-{2-[4-(Cyclohexyl-methyl-amino)-butoxy]-5-methoxy-phenyl}-benzothiazol-3-yl)-ethanone 
• 86135-27-5 1-(2-{2-[5-(Cyclohexyl-methyl-amino)-pentyloxy]-5-methoxy-phenyl}-benzothiazol-3-yl)-ethanone 

Relevant academic research and scientific papers

In situ generation of photoactivatable aggregation-induced emission probes for organelle-specific imaging

Photoactivatable fluorescent probes are ideal tools for organelle study with a significant advantage of high spatiotemporal resolution. However, conventional photo-caged fluorophores for organelle-specific imaging suffer from several drawbacks, such as aggregation-caused quenching (ACQ), instability under ambient light, low photoactivation efficiency, and toxic photo-cleavage byproducts. Herein, we propose a strategy for in situ generation of photoactivatable aggregation-induced emission (AIE) probes of 2-(2-hydroxyphenyl)-benzothiazolines from easily available disulfide and thiol substrates through tandem S-S bond reduction and intramolecular cyclization reaction. Because the photoactivatable AIE probes can be in situ generated in a quantitative yield, they can be directly used for bio-imaging without complicated separation steps. Under both one- and NIR two-photon irradiation, excellent spatiotemporal resolution and high photoactivation efficiency were achieved for specific imaging of lipid droplets and lysosomes, respectively. Based on their in situ generation and adjustable organelle-targeting ability, the photoactivatable AIE probes could become an easy-to-use imaging tool in the study of the biological functions of organelles.

Photoactivated aggregation-inducing luminescent probe having in-situ generation capability and preparation and application thereof

The invention belongs to the technical field of biological imaging, and discloses a photoactivated aggregation-inducing luminescent probe having in-situ generation capability and a preparation and application thereof. The preparation method comprises the following steps: reacting a bis(2-(2--hydroxybenzylidene)amino)aryldisulfide compound with a thiol to obtain the photoactivated aggregation-inducing luminescent probe, which has the structural formula III. The photoactivated aggregation-inducing luminescent probe is gathered in a specific organelle to produce a 2-(2-hydroxyphenyl)benzothiazolecompound having aggregation-inducing luminescent properties by photooxidation. The photoactivated aggregation-inducing luminescent probe having in-situ generation capability can effectively overcomethe defects of aggregation-induced quenching of traditional fluorescent dyes, and realize the organelle-targeting specific photo-activated fluorescence imaging in living cells, and has the advantagesof easy preparation, long-term storage, high light activation efficiency, large Stokes displacement, and strong ability to enter the cells.

Novel Calcium Antagonists. Synthesis and Structure-Activity Relationship Studies of Benzothiazoline Derivatives

A series of novel compounds having a benzothiazoline skeleton was studied for their structure-activity relationship (SAR) with respect to Ca2+ antagonist activity.As test compounds, analogues of 3-acyl-2-arylbenzothiazolines (3) were synthesize