306277-24-7Relevant academic research and scientific papers
Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists
Nguyen, Kevin T.,Claiborne, Christopher F.,McCauley, John A.,Libby, Brian E.,Claremon, David A.,Bednar, Rodney A.,Mosser, Scott D.,Gaul, Stanley L.,Connolly, Thomas M.,Condra, Cindra L.,Bednar, Bohumil,Stump, Gary L.,Lynch, Joseph J.,Koblan, Kenneth S.,Liverton, Nigel J.
, p. 3997 - 4000 (2008/02/10)
A novel series of cyclic benzamidines was synthesized and shown to exhibit NR2B-subtype selective NMDA antagonist activity. Compound 29 is orally active in a carrageenan-induced rat hyperalgesia model of pain.
CYCLIC AMIDINES USEFUL AS NMDA NR2B ANTAGONISTS
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, (2008/06/13)
The invention encompasses novel compounds of Formula I as well as a method of treating NMDA mediated diseases comprising administration to a patient in need of such treatment a non-toxic amount of a compound of Formula I effective to block the NMDA NR2B r
