306280-20-6

Basic information

• Product Name: 7-(2,6-dinitro-4-(trifluoromethyl)phenoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
• Synonyms: 7-(2,6-dinitro-4-(trifluoromethyl)phenoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
• CAS NO: 306280-20-6
• Molecular Formula: C₂₂H₁₁F₃N₂O₈
• Molecular Weight: 488.3265496
• Mol File: 306280-20-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-(2,6-dinitro-4-(trifluoromethyl)phenoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(2,6-dinitro-4-(trifluoromethyl)phenoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one(306280-20-6)
• EPA Substance Registry System: 7-(2,6-dinitro-4-(trifluoromethyl)phenoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one(306280-20-6)

Safety Data

• Hazardous Substances Data: 306280-20-6(Hazardous Substances Data)

Upstream product

• 393-75-9 4-chloro-3,5-dinitrobenzotrifluoride 
• 480-40-0 5,7-dihydroxy-2-phenyl-chromen-4-one 

Relevant articles and documents

Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors

The kinesin spindle protein (KSP) is involved in the formation of bipolar mitotic spindle during cell division and it becomes a new target to overcome the neurotoxicity of MTs inhibitors. A series of flavone and isoflavone derivatives (1a-7c) have been designed, synthesized and evaluated as potential KSP inhibitors. Among them, 2c displayed the most potent inhibitory activity in vitro, which inhibited the growth of MCF-7 and Hela cell lines with IC 50 values of 4.8 and 4.3 μM, respectively, and also exhibited significant KSP inhibitory activity (IC50 = 0.023 μM). The new compounds can induce irregular monoastral spindles, the characteristic phenotype for KSP inhibiting agents. Docking simulation was further performed to determine the probable binding model.