306288-41-5

Upstream product

• 64164-61-0 cholest-5-ene-3β,25-diol 3β,25-dibenzoate 
• 98-88-4 benzoyl chloride 
• 2140-46-7 25-hydroxychlolesterol 

Downstream Products

• 306288-44-8 cholest-5-ene-3β,7α,25-triol 3β,25-dibenzoate 
• 64907-22-8 [3H]-7alpha, 25-Dihydroxycholesterol 

Relevant academic research and scientific papers

Fluoro analogs of bioactive oxy-sterols: Synthesis of an EBI2 agonist with enhanced metabolic stability

Synthesis of several 7-hydroxy oxysterols and their potential roles as signaling molecules in the innate and adaptive immune responses is discussed. Discovery of a new, fluorinated, synthetic analog of the 7α,25-dihydroxycholesterol—the endogenous ligand of GPR 183 (EBI2), a G-protein coupled receptor highly expressed upon Epstein–Barr virus infection is described. Fluoro oxysterol 12 showed good metabolic stability while maintaining excellent EBI2 agonist activity.

Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols.

7alpha-Hydroxy derivatives of oxysterols are of considerable interest because of their possible involvement in regulation of cholesterol metabolism. This paper describes stereoselective syntheses and complete characterization of the 7alpha-hydroxy derivatives of four key oxysterols: 25-hydroxycholesterol, 27-hydroxycholesterol, 24(S)-hydroxycholesterol, and 24(S), 25-epoxycholesterol.