306305-10-2

Upstream product

• 233266-82-5 1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-D-ribo-pentofuranose 
• 1904-98-9 2,6-diaminopurine 
• 306305-09-9 9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine 

Downstream Products

• 1055039-87-6 thiocarbonic acid O-[4-benzyloxy-5-benzyloxymethyl-2-(2,6-diamino-purin-9-yl)-5-triethylsilanylethynyl-tetrahydro-furan-3-yl] ester O-phenyl ester 

Relevant academic research and scientific papers

4′-C-ethynyl pyrimidine nucleoside compounds and pharmaceutical compositions

The invention provides 4′-C-ethynyl pyrimidine nucleosides (other than 4′-C-ethynylthymidine) represented by formula [I]: wherein B represents a base selected from the group consisting of pyrimidine and derivatives thereof; X represents a hydrogen atom or

Syntheses of 4'-C-ethynyl-beta-D-arabino- and 4'-C-ethynyl-2'-deoxy-beta-D-ribo-pentofuranosylpyrimidines and -purines and evaluation of their anti-HIV activity.

4'-C-Ethynyl-beta-D-arabino- and 4'-C-ethynyl-2'-deoxy-beta-D-ribo-pentofuranosylpyrimidine and -purine nucleosides were synthesized and evaluated for their in vitro anti-HIV activity. The key intermediate, 4-C-ethynyl- or 4-C-triethylsilylethynyl-D-ribo-