30672-29-8

Basic information

• Product Name: 1,5-dimethyl-4-nitro-2-phenyl-1H-pyrazole-3(2H)-one
• Synonyms: 1,5-dimethyl-4-nitro-2-phenyl-1H-pyrazole-3(2H)-one
• CAS NO: 30672-29-8
• Molecular Weight: 233.227
• Mol File: 30672-29-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,5-dimethyl-4-nitro-2-phenyl-1H-pyrazole-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-dimethyl-4-nitro-2-phenyl-1H-pyrazole-3(2H)-one(30672-29-8)
• EPA Substance Registry System: 1,5-dimethyl-4-nitro-2-phenyl-1H-pyrazole-3(2H)-one(30672-29-8)

Safety Data

• Hazardous Substances Data: 30672-29-8(Hazardous Substances Data)

Upstream product

• 60-80-0 antipyrine 
• 10544-72-6 dinitrogen tetraoxide 
• 7697-37-2 nitric acid 
• 102748-20-9 bis-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-acetic acid 
• 885-11-0 1,5-dimethyl-4-nitroso-2-phenyl-1,2-dihydro-pyrazol-3-one 

Downstream Products

• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 
• 83-15-8 4-acetylaminoantipyrine 
• 1672-56-6 4-isobutylamino-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 15166-10-6 4-Ethylaminoantipyrin 
• 23934-85-2 4-(benzylamino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one 
• 860527-20-4 1,5-dimethyl-4-phenethylamino-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 34760-47-9 4-cyclohexylamino-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 58-15-1 aminopyrine 
• 102157-48-2 1,5-dimethyl-2-phenyl-4-(3-phenyl-propylamino)-1,2-dihydro-pyrazol-3-one 

Relevant articles and documents

Synthetic process of 4-ampyrone product

The invention provides a synthetic process of a 4-ampyrone product, which comprises the following steps of: preparing antipyrine and sulfuric acid with concentration of 40 to 60% into solution; enabling the solution and sodium nitrite solution to simultaneously flow into a nitrosation reactor, controlling flow rates of the solution and the sodium nitrite solution, and controlling a reaction temperature to be 45 to 50 DEG C; performing a reaction with stirring; testing a reaction endpoint by iodine powder and starch test paper to regulate a water flow rate; enabling nitroso antipyrine generated by nitrosation to immediately flow into a reducing pot to react with a reducing agent ammonium hydrogen sulfite prepared in the pot and aqueous solution of ammonium sulfite; carrying out sampling and measuring a pH value and a reduction degree; heating to a temperature of 90 to 100 DEG C; after hydrolysis, cooling to a temperature of 80 to 85 DEG C; neutralizing to pH of 7 to 7.5 by liquid ammonia; carrying out standing and layering. The process provided by the invention is simple, convenient to operate and high in yield.

AMINOPYRAZOLONE DERIVATIVE

The present invention is intended to provide a compound or a pharmacologically acceptable salt thereof which has an excellent inhibitory action on the ATPase activity of a TIP48/TIP49 complex and as such, is useful for the treatment of tumors. [Solution] The present invention provides a compound having a structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, and a pharmaceutical composition comprising the compound. In the formula, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the present specification.