885-11-0

Usage

Uses

Nitrosoantipyrine is a derivative of antipyrine (A697500), an analgesic agent.

InChI:InChI=1/C11H11N3O2/c1-8-10(12-16)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,1-2H3

Upstream product

• 60-80-0 antipyrine 
• 10544-72-6 dinitrogen tetraoxide 

Downstream Products

• 67523-71-1 4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylimino)-3-phenyl-4H-isoxazol-5-one 
• 102157-48-2 1,5-dimethyl-2-phenyl-4-(3-phenyl-propylamino)-1,2-dihydro-pyrazol-3-one 
• 58-15-1 aminopyrine 
• 34760-47-9 4-cyclohexylamino-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 860527-20-4 1,5-dimethyl-4-phenethylamino-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 15166-10-6 4-Ethylaminoantipyrin 
• 101116-41-0 1,5-dimethyl-2-phenyl-4-propylamino-1,2-dihydro-pyrazol-3-one 
• 1055-31-8 1,5,5'-trimethyl-2,2'-diphenyl-1,2,2',4'-tetrahydro-4,4'-azanylylidene-bis-pyrazol-3-one 
• 3615-24-5 ramifenazone 
• 6386-15-8 4-Isonitroso-3-methyl-pyrazolon-(5) 
• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 
• 30672-29-8 1,5-dimethyl-4-nitro-2-phenyl-1H-pyrazole-3(2H)-one 
• 1759-26-8 (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-sulfamic acid 
• 5702-68-1 N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pryazol-4-yl)benzamide 

Relevant academic research and scientific papers

Synthesis and structural characterization of lanthanum(III) complexes of 4-nitrosoantipyrine

A new series of La(III) complexes of the ligand with the general formula [La(L)2(a)3] and [La2(L)4(aa)3], (a = nitrate (1), thiocyanate (2), acetate (3) and propionate (4) ions, aa = sulphate (5), thiosulphate (6), oxalate (7) and malonate (8) ions with the ligand 4-nitrosoantipyrine (L) were synthesized and characterized using various physico-chemical studies. The primary ligand L acts as a bidentate ligand utilizing the carbonyl group and the nitroso group for bonding. The nitrate, thiocyanate, acetate and propionate ions are monovalent unidentate ligands, whereas sulphate, thiosulphate, oxalate and malonate ions are divalent bidentate ligands in the complexes 1-8. Based on spectral data and magnetic susceptibility measurements, geometry of the lanthanum(III) complexes were also proposed.

Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors

In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical characterization of the compounds was confirmed using IR, 1H NMR, 13C NMR and mass spectroscopies. The inhibitory potency of synthesized compounds was investigated towards acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and monoamine oxidases A and B (MAO-A and MAO-B) enzymes. Some of the compounds displayed significant inhibitory activity against AChE and MAO-B enzymes, respectively. According to AChE enzyme inhibition assay, compounds 3e and 3g were found as the most potent derivatives with IC50 values of 0.285 μM and 0.057 μM, respectively. Also, compounds 3a (IC50 = 0.114 μM), 3h (IC50 = 0.049 μM), and 3i (IC50 = 0.054 μM) were the most active derivatives against MAO-B enzyme activity. So as to understand inhibition type, enzyme kinetics studies were carried out. Furthermore, molecular docking studies were performed to define and evaluate the interaction mechanism between compounds 3g and 3h and related enzymes. ADME (Absorption, Distribution, Metabolism, and Excretion) and BBB (Blood, Brain, Barier) permeability predictions were applied to estimate pharmacokinetic profiles of synthesized compounds.

COMPARATIVE MASS SPECTROMETRIC BEHAVIOR OF o-HYDROXYNITROSO DERIVATIVES OF THE QUINOLINE, ISOQUINOLINE, AND COUMARIN SERIES

Benzo-substituted ortho-hydroxynitrosoquinoline and isoquinoline are found in the gas phase predominantly as the hydroxyimino-ortho-quinoid tautomeric form and under electron bombardment they do not undergo a second order Beckmann rearrangement.Molecular ions of 4-hydroxy-3-nitrosocarbostyryls and coumarin have almost exclusively the structure of the corresponding 2,4-dioxo-3-hydroxyiminohetarene; they also do not undergo rearrangement and decompose predominantly by retrodiene cleavage.