306725-99-5

Upstream product

• 306725-95-1 (2S,3S,5R,8R,9R,10R)-8-Benzyloxy-2-benzyloxymethyl-3-hydroxymethyl-1,4,6-trioxa-spiro[4.5]decane-9,10-diol 
• 306725-97-3 C₄₃H₅₀O₁₀Si 
• 306725-94-0 (2S,3S,8R,9S,10R)-9,10-Bis-allyloxy-2-allyloxymethyl-8-benzyloxy-3-benzyloxymethyl-1,4,6-trioxa-spiro[4.5]decane 
• 306725-96-2 (2S,3S,5S,8R,9R,10R)-8-Benzyloxy-2-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-1,4,6-trioxa-spiro[4.5]decane-9,10-diol 
• 98-88-4 benzoyl chloride 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 306725-98-4 C₂₉H₃₈O₁₀Si 

Downstream Products

• 306725-80-4 C₄₆H₆₆O₁₁Si₂ 
• 306726-50-1 (2S,3S,5S,8R,9R,10R)-8-Benzyloxymethoxy-2-((R)-hydroxy-thiazol-2-yl-methyl)-3-triisopropylsilanyloxymethyl-1,4,6-trioxa-spiro[4.5]decane-9,10-diol 
• 306726-00-1 C₄₀H₅₂O₁₁Si 
• 306726-01-2 C₄₃H₅₃NO₁₁SSi 
• 306726-02-3 C₄₉H₆₇NO₁₁SSi₂ 
• 306726-03-4 C₅₀H₅₄Br₃NO₁₂SSi 

Relevant academic research and scientific papers

Total synthesis of everninomicin 13,384-1 - Part 2: Synthesis of the FGHA2 fragment

The stereoselective synthesis of everninomicin's 13,384-1 (1) FGHA2 fragment (2) in a suitable form for incorporation into the final target (1) is described. The construction of the FG 1,1′-disaccharide linkage relied on a new method based on tin-acetal chemistry, while for the GH orthoester bridge, a number of approaches were explored. Final success for the latter construction came when a novel 1,2-phenylseleno migration reaction was applied to couple rings G and H, followed by ketene acetal and orthoester formation.