306739-55-9

Upstream product

• 122-84-9 4-methoxybenzyl methyl ketone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 

Downstream Products

• 94727-08-9 5-(4-methoxyphenyl)-4-methyl-2-(1H)-pyrimidinone 
• 84462-83-9 5-(4-methoxy-phenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 306739-65-1 4-benzamido-5-(4-methoxyphenyl)-2-(trifluoromethyl)pyridine 
• 306739-63-9 4-acetamido-5-(4-methoxyphenyl)-2-(trifluoromethyl)pyridine 
• 306739-61-7 4-amino-5-(4-methoxyphenyl)-2-(trifluoromethyl)pyridine 
• 306739-59-3 5-(4-methoxyphenyl)-2-(trifluoromethyl)-4-pyridinol 
• 306739-57-1 5-(4-methoxyphenyl)-2-(trifluoromethyl)-4H-pyran-4-one 

Relevant academic research and scientific papers

Substituted phenyl-2-(1H)-pyrimidinones useful for treating cardiac insufficiency in a warm-blooded organism

New substituted phenyl-2-(1H)-pyrimidinones of the general formula I STR1 in which R1 denotes an alkyl group having 1 to 4 carbon atoms, and R2 and R3, which can be identical or different, each denote hydrogen, halogen, cyano, a trifluoromethyl group, a hydroxyl group or an alkoxy group having 1 to 4 carbon atoms, it being possible for each alkyl moiety to be straight-chain or branched, and their tautomeric forms and their acid addition salts and N-oxides have a positive inotropic effect and can thus be used as medicaments for the treatment of cardiac insufficiency.

5-Substituted pyranone compounds and their use as pharmaceuticals to treat an immediate hypersensitivity condition

Compounds are described of the formula STR1 in which R1 is COOR5, CONHR5, cyano, 5-tetrazolyl or 5-tetrazolylaminocarbonyl, where R5 is hydrogen or C1-6 alkyl; R2 is hydrogen or C1-6 alkyl; R3 is a group of the formula where m is O or 1, Z is O, S, SO, SO2 or CO, and R6 phenyl optionally substituted by one or more group selected from halogen, C1-4 alkyl, C3-6 cycloalkyl, C1-4 alkoxy, benzyloxy, hydroxy, nitro, C1-4 alkylthio, C1-4 alkylsulphinyl, C1-4 alkylsulphonyl, amino and NHR7 where R7 is C2-6 acyl; and R4 is hydrogen, C1-6 alkyl or halogen; and salts thereof. These compounds have pharmaceutical properties and in particular are useful in the treatment of immediate hypersensitivity conditions such as asthma.