306776-74-9

Upstream product

• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 
• 1676-73-9 L-glutamic acid γ-benzyl ester 

Downstream Products

• 306776-77-2 1-(1-carbobenzyloxy-3-carbotertbutoxypropyl)-1,4,7,10-tetraazacyclododecane 
• 1049020-10-1 1,4,7,10-tetraazacyclododecane-1,7-bis(t-butyl acetate)-4,10-bis(glutaric acid 1-tert-butyl ester-5-benzyl ester) 
• 1044757-54-1 5-benzyl 1-tert-butyl 2-(1,4,8,11-tetraazabicyclo[6.6.2]hexadecan-4-yl)pentanedioate 
• 1196861-30-9 4,11-bis(1-(carbo-tert-butoxy)-3-(carbobenzyloxy)propyl)-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane 
• 306776-78-3 1-(1-carbobenzyloxy-3-carbotertbutoxypropyl)-4,7,10-(carbotertbutoxymethyl)-1,4,7,10-tetraazacyclododecane 
• 306776-79-4 (R,S)-5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic acid 

Relevant academic research and scientific papers

tBu4octapa-alkyl-NHS for metalloradiopeptide preparation

The peptide is an important class of biological targeting molecule; herein, a new bifunctional octadentate non-macrocyclic H4octapa,tBu4octapa-alkyl-NHS, which is compatible with solid-phase peptide synthesis and thus usef

MULTIVALENT SACCHARIDE COMPLEX, RADIOACTIVE MULTIVALENT SACCHARIDE COMPLEX CONTRAST AGENT, AND USE THEREOF

Disclosed herein are a multivalent saccharide complex, a radioactive multivalent saccharide complex contrast agent and use thereof. The multivalent saccharide complex has a chelator, a linker, and glucose, and is configured to diagnose and evaluate the th

Multifunctional linker technology containing an N4 group

In some aspects, the present disclosure provides compositions comprising an N4-based MMC ligand, a cell targeting group, and a fluorophore or a therapeutic compound comprising a formula: wherein the variables are as defined herein. In some embodiments, th

BISPHOSPHONIC ACID DERIVATIVE AND COMPOUND THEREOF LABELED WITH RADIOACTIVE METAL NUCLIDE

Disclosed is a radioactive bone diagnostic agent which gives a high ratio of radioactivity accumulation in bone to that in blood from an early stage after administration of the agent and allows capturing an image in a short time after administration. Also

METAL COMPLEXES OF TETRAAZAMACROCYCLE DERIVATIVES

Improved methods for synthesizing bifunctional chelates of tetraazamacrocycle derivatives and intermediates thereof are disclosed as well as novel tetraazamacrocycle derivatives and intermediates thereof.

A convenient synthesis of novel bifunctional prochelators for coupling to bioactive peptides for radiometal labelling

New DOTA-based bifunctional prochelators, e.g., 1-(1-carboxy-3-carbotertbutoxypropyl)-4,7,10-(carbotertbutoxymethyl)-1,4,7,10 -tetraazacyclodode-cane (DOTAGA(tBu)4), (6d) for a broad application in the modification of biomolecules with metal ions were prepared. The five-step synthesis of 6d has an overall yield of about 20%. The coupling of 6d to a bioactive peptide on solid-phase was exemplified with use of a CCK-B (cholecystokinin) analogue. (C) 2000 Elsevier Science Ltd.