30683-74-0Relevant academic research and scientific papers
An efficient preparation of stereospecific β-hydroxy nitriles
Jacobo, Sheila H.,Adiyaman, Mustafa,Chang, Chih-Tsung,Kang, Nam-In,Powell, William S.,Rokach, Joshua
, p. 161 - 164 (2005)
A new and convenient way to build a carbon-carbon bond is described. This methodology provides an efficient preparation of stereospecific β-hydroxy nitriles. The cyanide-ring opening of thionocarbonates with NaCN in DMF and TBACN in THF is described. This reaction occurred regioselectively to afford β-hydroxy nitrile with preserved stereochemistry of the hydroxy group in high yield.
