30696-04-9Relevant academic research and scientific papers
Significantly improved method for the pd-catalyzed coupling of phenols with aryl halides: Understanding ligand effects
Burgos, Carlos H.,Barder, Timothy E.,Huang, Xiaohua,Buchwald, Stephen L.
, p. 4321 - 4326 (2006)
(Chemical Equation Presented) A variety of diaryl ethers were synthesized by the Pd-catalyzed reaction of (hetero)-aryl halides and phenols. These reactions were achieved through the use of two new di-tert-butylphosphino biaryl ligands that overcome several limitations of previously described methods.
One-Pot Cross-Coupling/C-H Functionalization Reactions: Quinoline as a Substrate and Ligand through N-Pd Interaction
Bateman, Lorraine M.,Hickey, Aobha,Light, Mark E.,McGlacken, Gerard P.,Shanahan, Rachel M.
, p. 2585 - 2596 (2020/03/13)
Herein, we report a one-pot process that marries mechanistically distinct, traditional cross-coupling reactions with C-H functionalization using the same precatalyst. The reactions proceed in yields of up to 95%, in air, and require no extraneous ligand.
Metal-free regioselective formation of C-N and C-O bonds with the utilization of diaryliodonium salts in water: Facile synthesis of: N-Arylquinolones and aryloxyquinolines
Mehra, Manish Kumar,Tantak, Mukund P.,Arun,Kumar, Indresh,Kumar, Dalip
supporting information, p. 4956 - 4961 (2017/07/10)
Regioselective construction of crucial C-N and C-O bonds leading to N-Arylquinolones and aryloxyquinolines has been accomplished by employing easily accessible diaryliodonium salts and quinolones in water under metal-and ligand-free conditions. This opera
Microwave-Assisted Metal- and Ligand-Free O-Arylation of Quinolones Using Diaryliodonium Salts: An Easy and Rapid Synthesis of Aryloxyquinolines
Mehra, Manish Kumar,Tantak, Mukund P.,Kumar, Indresh,Kumar, Dalip
supporting information, p. 604 - 610 (2016/03/12)
A microwave-assisted metal- and ligand-free direct O-arylation of quinolones has been achieved by employing easily accessible diaryliodonium salts in the presence of a base to afford various aryloxyquinolines in good yields. The operationally simple and r
DESIGN, SYNTHESIS, AND BIOLOGICAL ACTIVITY OF PLATINUM-BENZ[C]ACRIDINE HYBRID AGENTS AND METHODS ASSOCIATED THEREWITH
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Page/Page column 27; 28, (2015/11/10)
The present invention relates to the compounds of formula (I), pharmaceutically acceptable salts, and solvates thereof, wherein the various substituents are as defined herein. The compounds, solvates and salts thereof of Formula (I) are effective as anti-cancer compounds.
Redesigning the DNA-Targeted chromophore in platinum-acridine anticancer agents: A structure-activity relationship study
Pickard, Amanda J.,Liu, Fang,Bartenstein, Thomas F.,Haines, Laura G.,Levine, Keith E.,Kucera, Gregory L.,Bierbach, Ulrich
supporting information, p. 16174 - 16187 (2015/02/19)
Platinum-acridine hybrid agents show low-nano-molar potency in chemoresistant non-small cell lung cancer (NSCLC), but high systemic toxicity in vivo. To reduce the promiscuous genotoxicity of these agents and improve their pharmacological properties, a mo
Effect of microwave heating on Ullmann-type heterocycle-aryl ether synthesis using chloro-heterocycles
D'Angelo, Noel D.,Peterson, Joseph J.,Booker, Shon K.,Fellows, Ingrid,Dominguez, Celia,Hungate, Randall,Reider, Paul J.,Kim, Tae-Seong
, p. 5045 - 5048 (2007/10/03)
Ullmann ether synthesis was conducted on a variety of chloro-heterocycles with different phenols using optimized conditions involving copper powder and cesium carbonate. On many substrates, microwave heating afforded higher yields in significantly shorter reaction times compared to conventional heating conditions. These findings provide a facile method for aryl ether synthesis from chloropyridines, chloroquinolines, and chlorobenzothiazoles.
