306979-31-7Relevant academic research and scientific papers
A general strategy for the synthesis of difluoromethyl-containing pyrazoles, pyridines and pyrimidines
Iaroshenko, Viktor O.,Specowius, Verena,Vlach, Katharina,Vilches-Herrera, Marcelo,Ostrovskyi, Dmytro,Mkrtchyan, Satenik,Villinger, Alexander,Langer, Peter
experimental part, p. 5663 - 5677 (2011/08/22)
Difluoromethyl-containing heteroannulated pyridines, pyrimidines and pyrazoles are prepared by a two step method. The regioselective cyclizations of electron-excessive aminoheterocycles, hydrazines and amidines with CF 2Cl-substituted 1,3-dicarbonyl compounds provide the corresponding CF2Cl-substituted heterocycles. Subsequent radical reactions with trimethylstannane or allyltrimethylstannane gave difluoromethyl-containing heteroannulated pyridines, pyrimidines and pyrazoles, respectively.
