307002-11-5Relevant academic research and scientific papers
A convenient synthesis of indole-substituted 2-pyrrolidones and their cyclized derivatives
Boisbrun, Michel,Jeannin, Laurent,Toupet, Loic,Laronze, Jean-Yves
, p. 3051 - 3057 (2007/10/03)
Condensation between indole, Meldrum's acid, and benzyloxycarbonylacetaldehyde or aminoacetaldehyde derivatives yielded trimolecular adducts 7a-c. The latter were cyclized to indole-substituted 2-pyrrolidones 15a-b or 3-aminopyrrolid-2-ones 18a-b, dependi
Stereochemically controlled syntheses of indole-substituted dihydrofuran-2-ones and a pyrrolidin-2-one
Boisbrun,Kovacs-Kulyassa,Jeannin,Sapi,Toupet,Laronze
, p. 9771 - 9775 (2007/10/03)
In order to obtain constrained analogues of tryptophane, five-membered lactams and lactones bearing 4-indolyl and 3-carboxylic groups were prepared in a completely diastereoselective manner, resulting in a trans relationship. Furthermore, the use of chira
