30708-54-4

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 107, p. 428, 1985 DOI: 10.1021/ja00288a025

Upstream product

• 3731-38-2 3-Quinuclidinone 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 186581-53-3 diazomethane 
• 1193-65-3 3-quinuclidinone hydrochloride 

Downstream Products

• 1220279-85-5 9-fluoro-6-[3-fluoro-4-(trifluoromethyl)benzyl]-3,4,5,6-tetrahydro-1H-2,5-ethanoazepino[4,3-b]indole trifluoroacetate 
• 1580437-71-3 1-azabicyclo[3.2.2]nonan-4-yl 1-(4-(4-fluorophenyl)pyrimidin-2-yl)piperidine-4-carboxylate 
• 1220278-15-8 9-(methylsulfonyl)-3,4,5,6-tetrahydro-1H-2,5-ethanoazepino[4,3-b]indole 
• 93756-96-8 C₁₅H₂₁N₃O₂S 
• 1312555-68-2 7-(benzyloxy)-3,4,5,6-tetrahydro-1H-2,5-ethanoazepino[4,3-b]indole 
• 1312555-40-0 7-[(E)-2-(4-chlorophenyl)vinyl]-3,4,5,6-tetrahydro-1H-2,5-ethanoazepino[4,3-b]indole 

Relevant academic research and scientific papers

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

BRIDGEHEAD AMINE RING-FUSED INDOLES AND INDOLINES

The present application relates to indole and indoline derivatives of formula (I), formula (II), formula (III), or formula (IV) wherein a, R2, R3, h, k, m, n, L, Q, X, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions.

AZINONE-SUBSTITUTED AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF

Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are als

INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF

The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety

Balanol is a potent protein kinase C (PKC) inhibitor that is structurally composed of a benzophenone diacid, a 4-hydroxybenzamide, and a perhydroazepine ring. A number of balanol analogs in which the perhydroazepine moiety is replaced have been synthesized and their biological activities evaluated against both PKC and cAMP-dependent kinase (PKA). The results suggested that the activity and the isozyme/kinase selectivity of these compounds are largely related to the conformation about this nonaromatic structural element of the molecules.

Conjugative Interaction in the Orthogonal Enamine, 1-Azabicyclonon-2-ene

Synthesis of 1-azabicyclonon-3-ene and establishment of equilibrium with 1-azabicyclonon-2-ene by catalysis either with potassium tert-butyloxide or hydridonitrosotris(triphenylphosphine)ruthenium reveals no free energy difference between th