1193-65-3Relevant articles and documents
Preparation method of optical activity 3-quinuclidinol
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Paragraph 0013; 0014, (2018/04/03)
The invention relates to an intermediate synthesis method, belongs to the field of organic synthesis, and particularly relates to a preparation method of optical activity 3-quinuclidinol with the advantages that the operation is simple and convenient, the cost is low, and the method is suitable for industrial production. An intermediate of 3-quinuclidinol is obtained by using 4-nipecotic acid as astarting material through esterification, nucleophilic substitution, Dieckmann condensation, decarboxylation, salification, reduction, acetylization, chemical resolution and the like. The reaction formula is shown in the description.
Copper(I)/ABNO-catalyzed aerobic alcohol oxidation: Alleviating steric and electronic constraints of Cu/TEMPO catalyst systems
Steves, Janelle E.,Stahl, Shannon S.
supporting information, p. 15742 - 15745 (2013/11/06)
Cu/TEMPO catalyst systems promote efficient aerobic oxidation of sterically unhindered primary alcohols and electronically activated substrates, but they show reduced reactivity with aliphatic and secondary alcohols. Here, we report a catalyst system, consisting of (MeObpy)CuI(OTf) and ABNO (MeObpy =4,4′-dimethoxy-2,2′-bipyridine; ABNO = 9-azabicyclo[3.3.1]nonane N-oxyl), that mediates aerobic oxidation of all classes of alcohols, including primary and secondary allylic, benzylic, and aliphatic alcohols with nearly equal efficiency. The catalyst exhibits broad functional group compatibility, and most reactions are complete within 1 h at room temperature using ambient air as the source of oxidant.
SYNTHESIS AND PROPERTIES OF 2-ETHOXYCARBONYL-3-AMINO-2,3-DEHYDROQUINUCLIDINE
Vorob'eva, V. Ya.,Mikhlina, E. E.,Turchin, K. F.,Yakhontov, L. N.
, p. 782 - 785 (2007/10/02)
The reduction of 2-ethoxycarbonyl-3-oxoquinuclidine oxime hydrochloride leads to 2-ethoxycarbonyl-3-amino-2,3-dehydroquinuclidine, from which pyrimidoquinuclidine derivatives were obtained by reaction with formamide, methyl isocyanate, and phenyl isocyanate.It is shown that 7-hydroxypyrazoloquinuclidine is formed in the reaction of 2-ethoxycarbonyl-3-acetamido-2,3-dehydroquinuclidine with hydrazine hydrate.