307308-48-1Relevant academic research and scientific papers
Synthesis of phloroglucinol monoaryl ethers
Sherwood, Alexander M.,Pond, David M.,Trudell, Mark L.
experimental part, p. 1208 - 1212 (2012/05/20)
A variety of novel functionalized phloroglucinol monoaryl ethers have been synthesized using a two-step procedure. Target ethers were synthesized by coupling electron-deficient aryl fluorides with 3,5-dimethoxyphenol via nucleophilic aromatic substitution (SNAr) in N-methylpyrrolidone and cesium carbonate. Subsequent boron tribromide-mediated demethylation gave a series of phloroglucinol monoaryl ethers in good overall yields. Georg Thieme Verlag Stuttgart New York.
Synthesis of de novo designed small-molecule inhibitors of bacterial RNA polymerase
Agarwal, Anil K.,Johnson, A. Peter,Fishwick, Colin W.G.
, p. 10049 - 10054 (2008/12/22)
The de novo molecular design program SPROUT has been used in conjunction with the X-ray crystal structure of RNA polymerase (RNAP) from Thermus aquaticus to produce a novel enzyme inhibitor scaffold. A?short and efficient synthesis of molecules corresponding to this scaffold has been developed and in keeping with the design predictions, the resulting inhibitors displayed useful levels of inhibition of Escherichia coli RNAP.
