307318-56-5Relevant articles and documents
Synthesis of new aromatic (C17-C20)-locked side-chain analogues of calcitriol (1α,25-dihydroxyvitamin D3)
Fernandez-Gacio,Vitale,Mourino
, p. 6978 - 6983 (2007/10/03)
The synthesis of four new analogues of calcitriol (1α,25-(OH)2-D3) possessing aromatic and conjugated double bond units at the side chain are described. The triene system is introduced using the Lythgoe-Hoffmann La Roche convergent Wittig-Horner approach. The key steps in the preparation of the requisite upper fragments are the introduction of the side chain with the E-conjugated aromatic system and its photochemical conversion to the Z counterpart.