282724-94-1

Basic information

• Product Name: 8β-tert-butyldimethylsilyloxy-(17E)-{1-[3-(methyloxycarbonyl)phenyl]methylidene}-de-A,B-androstane
• Synonyms: 8β-tert-butyldimethylsilyloxy-(17E)-{1-[3-(methyloxycarbonyl)phenyl]methylidene}-de-A,B-androstane
• CAS NO: 282724-94-1
• Molecular Weight: 414.66
• Mol File: 282724-94-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8β-tert-butyldimethylsilyloxy-(17E)-{1-[3-(methyloxycarbonyl)phenyl]methylidene}-de-A,B-androstane(CAS DataBase Reference)
• NIST Chemistry Reference: 8β-tert-butyldimethylsilyloxy-(17E)-{1-[3-(methyloxycarbonyl)phenyl]methylidene}-de-A,B-androstane(282724-94-1)
• EPA Substance Registry System: 8β-tert-butyldimethylsilyloxy-(17E)-{1-[3-(methyloxycarbonyl)phenyl]methylidene}-de-A,B-androstane(282724-94-1)

Safety Data

• Hazardous Substances Data: 282724-94-1(Hazardous Substances Data)

Upstream product

• 128833-03-4 P-[(3-bromophenyl)methyl]phosphonic acid diethyl ester 
• 140659-26-3 8β-[(tert-butyldimethylsilyl)oxy]de-A,B-androstan-17β-one 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 282724-83-8 8β-tert-butyldimethylsilyloxy-(17E)-[1-(3-bromophenyl)methylidene]-de-A,B-androstane 

Downstream Products

• 307318-52-1 (17E)-1α-tert-butyldimethylsilyloxy-20-[3-(dimethylhydroxymethyl)phenyl]-17,20-didehydro-21,22,23,24,25,26,27-heptanorvitamin D₃ tert-butyldimethylsilyl ether 
• 307318-57-6 (17Z)-1α-tert-butyldimethylsilyloxy-20-[3-(dimethylhydroxymethyl)phenyl]-17,20-didehydro-21,22,23,24,25,26,27-heptanorvitamin D₃ tert-butyldimethylsilyl ether 
• 307318-51-0 (17E)-1α-tert-butyldimethylsilyloxy-20-[3-(methyloxycarbonyl)phenyl]-17,20-didehydro-21,22,23,24,25,26,27-heptanorvitamin D₃ tert-butyldimethylsilyl ether 
• 307318-56-5 (17Z)-1α-tert-butyldimethylsilyloxy-20-[3-(methyloxycarbonyl)phenyl]-17,20-didehydro-21,22,23,24,25,26,27-heptanorvitamin D₃ tert-butyldimethylsilyl ether 
• 307318-55-4 (17Z)-{1-[3-(methyloxycarbonyl)phenyl]methylidene}-de-A,B-androstan-8β-ol 
• 307318-48-5 (17E)-{1-[3-(methyloxycarbonyl)phenyl]methylidene}-de-A,B-androstan-8-one 
• 307318-49-6 (17Z)-{1-[3-(methyloxycarbonyl)phenyl]methylidene}-de-A,B-androstan-8-one 
• 307318-54-3 8β-tert-butyldimethylsilyloxy-(17Z)-{1-[3-(methyloxycarbonyl)phenyl]methylidene}-de-A,B-androstane 
• 307318-50-9 (17E)-{1-[3-(methyloxycarbonyl)phenyl]methylidene}-de-A,B-androstan-8β-ol 

Relevant articles and documents

Synthesis of new aromatic (C17-C20)-locked side-chain analogues of calcitriol (1α,25-dihydroxyvitamin D3)

The synthesis of four new analogues of calcitriol (1α,25-(OH)2-D3) possessing aromatic and conjugated double bond units at the side chain are described. The triene system is introduced using the Lythgoe-Hoffmann La Roche convergent Wittig-Horner approach. The key steps in the preparation of the requisite upper fragments are the introduction of the side chain with the E-conjugated aromatic system and its photochemical conversion to the Z counterpart.