307325-55-9Relevant academic research and scientific papers
Design, synthesis, and pharmacological characterization of some 2-substituted-3-phenyl-quinazolin-4(3H)-one derivatives as phosphodiesterase inhibitors
Amin, Kamilia M.,Hegazy, Gehan H.,George, Riham F.,Ibrahim, Nahla R.,Mohamed, Nada M.
, (2021/05/13)
Some 3-phenyl-quinazolin-4(3H)-one-2-thioethers (3a–e, 5a,b, 7a–e, 9a–d, 10a–d, and 12) along with 2-aminoquinazoline derivatives 13a–c were prepared and screened for their in vitro phosphodiesterase (PDE) inhibitory activity. Some compounds such as 7d,e,
Design, synthesis and anticonvulsant activity of some newer 3H-quinazolin-4-one derivatives
Amir, Mohd,Ali, Israr,Hassan, Mohd Zaheen
, p. 597 - 604 (2014/06/23)
In the present investigation, a series of 2-[2-(aryl)-2-oxo-ethylsulfanyl]- 3-(aryl/propyl)-3H-quinazolin-4-ones have been synthesized and tested for their potential against seizures in mice. All the newly synthesized compounds show moderate to high protection against 6 Hz partial seizure with compound 2b, 2-(2-oxo-2-p-tolyl-ethylsulfanyl)-3-phenyl-3H-quinazolin-4-one emerging as the most active anticonvulsant agent endowed with neuroprotective effect against NMDA and kainate induced excitotoxicity. The results of whole brain GABA assay indicates that the seizure protective activity of 2b can be either due to the increased brain GABA level or due to neuroprotective action.
Design, synthesis, and anticonvulsant activity of novel quinazolinone analogues
Gawad, Nagwa M. Abdel,Georgey, Hanan Hanna,Youssef, Riham M.,Sayed, Nehad A. El
experimental part, p. 1280 - 1286 (2012/05/20)
A number of 2-substituted and 2,3-disubstituted quinazolinone analogues have been synthesized. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, 1H NMR, and MS). An evaluation of the anticon
