307353-95-3

Basic information

• Product Name: 3-Quinolinecarbonitrile, 4-chloro-6-hydroxy-7-Methoxy-
• Synonyms: 3-Quinolinecarbonitrile, 4-chloro-6-hydroxy-7-Methoxy-;4-chloro-6-hydroxy-7-methoxyquinoline-3-carbonitrile
• CAS NO: 307353-95-3
• Molecular Formula: C₁₁H₇ClN₂O₂
• Molecular Weight: 234.63848
• Mol File: 307353-95-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 416.238°C at 760 mmHg
• Flash Point: 205.533°C
• Appearance: /
• Density: 1.488g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.677
• PKA: 7.91±0.40(Predicted)
• CAS DataBase Reference: 3-Quinolinecarbonitrile, 4-chloro-6-hydroxy-7-Methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarbonitrile, 4-chloro-6-hydroxy-7-Methoxy-(307353-95-3)
• EPA Substance Registry System: 3-Quinolinecarbonitrile, 4-chloro-6-hydroxy-7-Methoxy-(307353-95-3)

Safety Data

• Hazardous Substances Data: 307353-95-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H7ClN2O2/c1-16-10-3-8-7(2-9(10)15)11(12)6(4-13)5-14-8/h2-3,5,15H,1H3

Upstream product

• 31839-20-0 5-hydroxy-4-methoxy-2-nitrobenzoic acid 
• 215659-03-3 methyl 5-hydroxy-4-methoxy-2-nitrobenzoate 
• 164161-49-3 methyl 5-(benzyloxy)-4-methoxy-2-nitrobenzoate 
• 855793-63-4 methyl 2-amino-5-(benzyloxy)-4-methoxybenzoate 
• 15382-71-5 4-(benzyloxy)-3-methoxyaniline 

Relevant articles and documents

HETEROCYCLIC INHIBITORS OF TYROSINE KINASE

The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of HER2 or EGFR for the treatment or prevention of disease, including cancer.

Substituted quinolines as antitumor agents

The invention provides a compound of Formula (Ia), or a pharmaceutically acceptable salt. prodrug or solvate thereof. The invention also provides a process for the preparation of a compound of Formula (Ia), pharmaceutical compositions of a compound of Formula (Ia) and methods for the treatment or prevention of cancer comprising administering an effective amount of a compound of Formula (Ia).