15382-71-5

Usage

InChI:InChI=1/C14H15NO2/c1-16-14-9-12(15)7-8-13(14)17-10-11-5-3-2-4-6-11/h2-9H,10,15H2,1H3

Upstream product

• 100-39-0 benzyl bromide 
• 3251-56-7 2-methoxy-4-nitrophenol 
• 100200-99-5 potassium 2-methoxy-4-nitrophenolate monohydrate 
• 107922-43-0 1-(benzyloxy)-2-methoxy-4-nitrobenzene 

Downstream Products

• 62035-70-5 N-(4-Benzyloxy-3-methoxy-phenyl)-benzenesulfonamide 
• 187960-39-0 7-Benzyloxy-6-methoxy-1,2,3,4-tetrahydro-acridin-9-ylamine 
• 187960-37-8 7-Benzyloxy-9-chloro-6-methoxy-1,2,3,4-tetrahydro-acridine 
• 187960-34-5 7-Benzyloxy-6-methoxy-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 187960-43-6 (7-Benzyloxy-6-methoxy-1,2,3,4-tetrahydro-acridin-9-yl)-heptyl-amine 
• 62035-68-1 N-(4-Benzyloxy-2-bromo-5-methoxy-phenyl)-benzenesulfonamide 
• 307353-95-3 4-chloro-6-hydroxy-7-methoxyquinoline-3-carbonitrile 

Relevant academic research and scientific papers

Photochemical C–H Activation: Generation of Indole and Carbazole Libraries, and First Total Synthesis of Clausenawalline D

The photolysis of N-aryltriazoles and N-arylbenzotriazoles leads to indoles and carbazoles, respectively. Because libraries of triazoles can be accessed rapidly, for example by the copper-catalyzed [3+2] cycloaddition reaction between alkynes and azides, this reaction allows the preparation of indoles in a single operation, by the simultaneous photolysis of the precursor library. As an example of such a synthesis of carbazoles, we prepared for the first time clausenawalline D, an antimalarial alkaloid that was recently isolated.

Oxidative Routes to the Heterocyclic Cores of Benzothiazole Natural Products

Methyl 6-(2-acetylaminoethyl)-4-hydroxy-benzothiazole-2-carboxylate, the benzothiazole core of the natural product violatinctamine, was prepared in a biomimetic oxidative route from N-acetyldopamine and cysteine methyl ester. In an alternative oxidative cyclization, ethyl 6-benzyloxy-5-methoxybenzo[d]thiazole-2-carboxylate, the heterocyclic core of erythrazole A, was also prepared.

Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase

3-Amido-4-anilinoquinolines are potent and highly selective inhibitors of CSF-1R. Their synthesis and SAR is reported, along with initial efforts to optimize the physical properties and PK through modifications at the quinoline 6- and 7-positions.

COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

The present invention provides compounds of formula (I) or compounds of formula (II) and pharmaceutically acceptable salts or solvates thereof. An objective of the present invention is to provide compounds having TGF2 inhibitory activity.