307498-59-5

Upstream product

• 111-70-6 n-heptan1ol 
• 80407-63-2 3-(heptyloxy)benzaldehyde 
• 621-54-5 3-(3-hydroxyphenyl)-propanoic acid 
• 629-04-9 1-Bromoheptane 
• 61389-68-2 methyl 3-(3-hydroxyphenyl)propionate 
• 100-83-4 meta-hydroxybenzaldehyde 
• 307498-57-3 (E)-3-(3-Heptyloxy-phenyl)-acrylic acid methyl ester 

Downstream Products

• 307498-67-5 5-(3-heptyloxy-phenyl)-3-hydroxy-pentanoic acid 
• 307498-64-2 1-(3-heptyloxy-phenyl)-hex-5-en-3-ol 
• 307498-61-9 3-(3-heptyloxy-phenyl)-propionaldehyde 

Relevant academic research and scientific papers

Structure-activity relationships of lysophosphatidylserine analogs as agonists of G-protein-coupled receptors GPR34, P2Y10, and GPR174

Lysophosphatidylserine (LysoPS) is an endogenous lipid mediator generated by hydrolysis of membrane phospholipid phosphatidylserine. Recent ligand screening of orphan G-protein-coupled receptors (GPCRs) identified two LysoPS-specific human GPCRs, namely, P2Y10 (LPS2) and GPR174 (LPS3), which, together with previously reported GPR34 (LPS1), comprise a LysoPS receptor family. Herein, we examined the structure-activity relationships of a series of synthetic LysoPS analogues toward these recently deorphanized LysoPS receptors, based on the idea that LysoPS can be regarded as consisting of distinct modules (fatty acid, glycerol, and l-serine) connected by phosphodiester and ester linkages. Starting from the endogenous ligand (1-oleoyl-LysoPS, 1), we optimized the structure of each module and the ester linkage. Accordingly, we identified some structural requirements of each module for potency and for receptor subtype selectivity. Further assembly of individually structure-optimized modules yielded a series of potent and LysoPS receptor subtype-selective agonists, particularly for P2Y10 and GPR174.

COMPOUND EXHIBITING REGULATORY ACTIVITY ON LYSOPHOSPHATIDYLSERINE RECEPTOR FUNCTION

The object of the present invention is to provide a compound having a lysophosphatidylserine receptor function modulation activity or a salt thereof. A compound having a lysophosphatidylserine receptor function modulation activity or a salt thereof, or a pharmaceutical composition or a lysophosphatidylserine receptor function moderator containing such compound or salt is provided by the present invention.

Syntheses and antifungal activity of pseudomycin side-chain analogues. Part 1

We have described herein the syntheses of three novel series of aromatic ring containing pseudomycin side-chain analogues. Preliminary biological evaluations of these analogues clearly indicate that it is possible to synthesize rigid pseudomycin side-chain analogues without compromising in vitro antifungal activity. (C) 2000 Elsevier Science Ltd.