80407-63-2Relevant academic research and scientific papers
Syntheses and antifungal activity of pseudomycin side-chain analogues. Part 1
Jamison, James,Levy, Stuart,Sun, Xicheng,Zeckner, Doug,Current, William,Zweifel, Mark,Rodriguez, Michael,Turner, William,Chen, Shu-Hui
, p. 2101 - 2105 (2007/10/03)
We have described herein the syntheses of three novel series of aromatic ring containing pseudomycin side-chain analogues. Preliminary biological evaluations of these analogues clearly indicate that it is possible to synthesize rigid pseudomycin side-chain analogues without compromising in vitro antifungal activity. (C) 2000 Elsevier Science Ltd.
Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase
Chowdhury, Shafinaz F.,Villamor, Victor Bernier,Guerrero, Ramon Hurtado,Leal, Isabel,Brun, Reto,Croft, Simon L.,Goodman, Jonathan M.,Maes, Louis,Ruiz-Perez, Luis M.,Pacanowska, Dolores Gonzalez,Gilbert, Ian H.
, p. 4300 - 4312 (2007/10/03)
This paper concerns the design, synthesis, and evaluation of inhibitors of leishmanial and trypanosomal dihydrofolate reductase. Initially study was made of the structures of the leishmanial and human enzyme active sites to see if there were significant d
