3075-23-8

Basic information

• Product Name: 3-Oxothiobutyric acid S-ethyl ester
• Synonyms: 3-Oxobutanethioic acid S-ethyl ester;3-Oxothiobutyric acid S-ethyl ester;S-Ethyl acetothioacetate
• CAS NO: 3075-23-8
• Molecular Formula: C₆H₁₀O₂S
• Molecular Weight: 146.21
• Mol File: 3075-23-8.mol
• Article Data: 1

Chemical Properties

• Flash Point: 80℃
• Appearance: /
• Density: 1.092 g/mL at 25 °C
• Refractive Index: n20/D1.495
• CAS DataBase Reference: 3-Oxothiobutyric acid S-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Oxothiobutyric acid S-ethyl ester(3075-23-8)
• EPA Substance Registry System: 3-Oxothiobutyric acid S-ethyl ester(3075-23-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• RIDADR: UN 3334
• WGK Germany: 3
• Hazardous Substances Data: 3075-23-8(Hazardous Substances Data)

Upstream product

• 625-60-5 ethyl thioacetate 
• 105-37-3 Ethyl propionate 

Downstream Products

• 520-45-6 Dehydracetic acid 
• 111677-43-1 2-Methyl-5,5-dioxo-4-phenyl-4,5-dihydro-1H-5λ⁶-benzo[4,5]thieno[3,2-b]pyridine-3-carbothioic acid S-ethyl ester 
• 75926-34-0 2,6-Dimethyl-3,5-bis(ethylthiocarbonyl)-4-phenyl-1,4-dihydropyridine 
• 2469-99-0 Cyanoaceton 
• 1693-94-3 2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 
• 1203706-71-1 (S)-S-ethyl 2-((R)-(tert-butoxycarbonylamino)(phenyl)methyl)-3-oxobutanethioate 
• 81635-76-9 1,2,6-Trimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarbothioic acid di-S-ethyl ester 
• 81635-64-5 OSI-4164 
• 81635-66-7 5-Ethylsulfanylcarbonyl-2,6-dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 81635-70-3 2,6-Dimethyl-4-(4-nitro-phenyl)-pyridine-3,5-dicarbothioic acid di-S-ethyl ester 

Relevant articles and documents

Acylations of Thiol Ester Enolate Anions

The synthetic utility of thiol ester anions has been explored.Claisen condensations of thiol esters with isopropylmagnesium bromide base proceed in good yield.The Dieckmann reaction of diethyl thiolpimelate to form a six-membered ring proceeds in 74 percent yield, but the corresponding reaction of diethyl thioladipate to provide a five-membered ring gives only 26 percent yield.Neither alkylation of ethyl thiolacetate nor a Michael-type adduct with methyl vinyl ketone could be achieved.The mechanism of the Claisen condensation as it applies to thiol esters is discussed.