625-60-5

Basic information

• Product Name: Ethanethioic acid S-ethyl ester
• Synonyms: Ethyl thioacetate, 97+%;S-Ethylthioacetate,98+%;Ethanethioic acid S-ethyl este;Acetic acid, thio-, S-ethyl ester;CH3COSC2H5;Ethyl thiolacetate;S-Ethyl ethanethioate;S-Ethyl thiolacetate
• CAS NO: 625-60-5
• Molecular Formula: C₄H₈OS
• Molecular Weight: 104.17
• EINECS: 210-904-9
• Product Categories: API intermediates;thioester Flavor;Alphabetical Listings;E-F;Flavors and Fragrances
• Mol File: 625-60-5.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 116 °C(lit.)
• Flash Point: 65 °F
• Appearance: /
• Density: 0.979 g/mL at 25 °C(lit.)
• Vapor Pressure: 18.2mmHg at 25°C
• Refractive Index: n20/D 1.458(lit.)
• Water Solubility: Insoluble in water
• BRN: 1737643
• CAS DataBase Reference: Ethanethioic acid S-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanethioic acid S-ethyl ester(625-60-5)
• EPA Substance Registry System: Ethanethioic acid S-ethyl ester(625-60-5)

Safety Data

• Hazard Codes: F,Xn
• Statements: 11-22-37/38-41-20/21/22
• Safety Statements: 26-39-36/37-23-16
• RIDADR: UN 1993 3/PG 2
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 625-60-5(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 625-60-5 differently. You can refer to the following data:
1. Colorless liquid
2. Ethyl thioacetate has an alliaceous, coffee odor

Occurrence

Reported found in beer, white wine, red wine, rose wine, durian (Durio zibethinus) and coffee.

Preparation

From acetyl chloride and ethyl mercaptan.

Taste threshold values

Taste characteristics at 10 ppm: sulfuraceous, onion-garlic with a sweet, fruity aftertaste.

General Description

Ethyl thioacetate is a volatile sulfur compound that is reported to occur in durian fruit and wine.

InChI:InChI=1/C4H8OS/c1-3-6-4(2)5/h3H2,1-2H3

Upstream product

• 352-93-2 diethyl sulphide 
• 507-02-8 acetyl iodide 
• 108-24-7 acetic anhydride 
• 75-08-1 ethanethiol 
• 34832-35-4 sodium thioacetate 
• 75-03-6 ethyl iodide 
• 1486-42-6 diethyl phosphorochloridodithioite 
• 75-36-5 acetyl chloride 
• 688-62-0 triethyl trithiophosphite 
• 1486-39-1 S,S,S-triethyl phosphorotrithioate 
• 7299-53-8 ethylthioacetylene 
• 64-19-7 acetic acid 
• 10499-97-5 trithioorthobenzoic acid triethyl ester 
• 40618-45-9 O,S-diethylphenylthiophosphonite 

Downstream Products

• 2469-99-0 Cyanoaceton 
• 17620-90-5 3-(triphenyl-λ⁵-phosphanylidene)-hexan-2-one 
• 870-73-5 ethyl dithioacetate 
• 103108-32-3 anti-ethyl 3-hydroxy-4-phenylthiopentanoate 
• 103108-32-3 syn-ethyl 3-hydroxy-4-phenylthiopentanoate 
• 142947-91-9 ethyl (S)-4-<(tert-butyloxycarbonyl)amino>-3-oxo-7-(3-tosylguanidino)thioheptanoate 
• 110-81-6 Diethyl disulfide 
• 19479-87-9 (O-carboxymethyl)hydroxylamine 
• 546-88-3 acetylhydroxamic acid 
• 463-51-4 Ketene 
• 74-85-1 ethene 
• 75-07-0 acetaldehyde 
• 75-08-1 ethanethiol 
• 594-45-6 ethanesulfonic acid 

Relevant articles and documents

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Silver triflate catalyzed acetylation of alcohols, thiols, phenols, and amines

A variety of alcohols, thiols, phenols, and amines were subjected to acetylation reaction using acetic anhydride in the presence of catalytic quantity of silver triflate. The method described has a wide range of applications, proceeds under mild conditions, does not involve cumbersome workup, and the resulting products are obtained in high yields within a reasonable time. Georg Thieme Verlag Stuttgart · New York.

Facile catalyzed acylation of heteroatoms using BiCl3 generated in situ from the procatalyst BiOCl and acetyl chloride

Acylation of a variety of alcohols, phenols, aliphatic and aromatic amines, a thiol and a thiophenol proceeds efficiently using BiCl3 generated in situ from the procatalyst BiOCl and acetyl chloride in a solvent or under solventless conditions, furnishing the corresponding acylated derivatives in very good to excellent yields.