30765-81-2

Basic information

• Product Name: N-allyl-N-(4-methoxyphenyl)benzenesulfonamide
• Synonyms: N-allyl-N-(4-methoxyphenyl)benzenesulfonamide
• CAS NO: 30765-81-2
• Molecular Weight: 303.382
• Mol File: 30765-81-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-allyl-N-(4-methoxyphenyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-allyl-N-(4-methoxyphenyl)benzenesulfonamide(30765-81-2)
• EPA Substance Registry System: N-allyl-N-(4-methoxyphenyl)benzenesulfonamide(30765-81-2)

Safety Data

• Hazardous Substances Data: 30765-81-2(Hazardous Substances Data)

Upstream product

• 1228392-90-2 C₁₆H₁₆BrNO₃S 
• 104-94-9 4-methoxy-aniline 
• 7471-26-3 N-(4-methoxyphenyl)benzenesulphonamide 
• 106-95-6 allyl bromide 
• 98-09-9 benzenesulfonyl chloride 

Relevant articles and documents

Ultrasound-assisted one-pot three-component synthesis of new isoxazolines bearing sulfonamides and their evaluation against hematological malignancies

In the present study, following a one-pot two-step protocol, we have synthesized novel sulfonamides-isoxazolines hybrids (3a-r) via a highly regioselective 1,3-dipolar cycloaddition. The present methodology capitalized on trichloroisocyanuric acid (TCCA) as a safe and ecological oxidant and chlorinating agent for the in-situ conversion of aldehydes to nitrile oxides in the presence of hydroxylamine hydrochloride, under ultrasound activation. These nitrile oxides could be engaged in 1,3-dipolar cycloaddition reactions with various alkene to afford the targeted sulfonamides-isoxazolines hybrids (3a-r). The latter were assessed for their antineoplastic activity against model leukemia cell lines (Chronic Myeloid Leukemia, K562 and Promyelocytic Leukemia, HL-60).