307950-45-4Relevant academic research and scientific papers
Facile One-Pot Synthesis of Methyl 1-Aryl-1H-1,2,4-triazole-3-carboxylates from Nitrilimines with Vilsmeier Reagent
Tsai, Shuo-En,Chiang, Kun-Heng,Tseng, Ching-Chun,Chen, Nai-Wei,Chern, Ching-Yuh,Wong, Fung Fuh
, p. 1754 - 1762 (2019/02/24)
Two convenient and effective one-pot methods have been developed to synthesize methyl 1-aryl-1H-1,2,4-triazole1–3-carboxylates by using hydrazonoyl hydrochlorides (nitrilimines) with Vilsmeier reagent. The first, a direct one-pot method, involved the reac
A Multicomponent Electrosynthesis of 1,5-Disubstituted and 1-Aryl 1,2,4-Triazoles
Yang, Na,Yuan, Gaoqing
, p. 11963 - 11969 (2018/09/25)
A novel electrochemical route has been developed for the synthesis of 1,5-disubstituted and 1-aryl 1,2,4-triazoles from aryl hydrazines, paraformaldehyde, NH4OAc, and alcohols. In this multicomponent reaction system, alcohols act as solvents as well as reactants and NH4OAc is used as the nitrogen source. With the assistance of reactive iodide radical or I2 and NH3 electrogenerated in situ, this process could effectively avoid the use of strong oxidants and transition-metal catalysts and be smoothly carried out at room temperature to give a wide array of 1,2,4-triazole derivatives in good to high yields. Preliminary studies reveal that the reaction mechanism involves a radical process.
Triazole-substituted nitroarene derivatives: Synthesis, characterization, and energetic studies
Kommu, Nagarjuna,Ghule, Vikas D.,Kumar, A. Sudheer,Sahoo, Akhila K.
supporting information, p. 166 - 178 (2014/01/06)
A series of dense and energetic polynitroaryl-1,2,4-triazoles were synthesized through the nitration of aryl-1,2,4-triazoles. The Cu-catalyzed/base-mediated coupling reactions of haloarenes with 1,2,4-triazoles delivered N-aryl-1,2,4-triazoles. These new
