308103-74-4Relevant academic research and scientific papers
Synthesis of axinohydantoins
Barrios Sosa, Ana Carolina,Yakushijin, Kenichi,Horne, David A.
, p. 4498 - 4500 (2002)
A short synthesis of the hydantoin-containing marine sponge metabolites axinohydantoins is described. A key feature of the synthesis is a putative biomimetic, intramolecular cyclization of α-functionalized imidazolone 5, which affords the tricyclic pyrroloazepinone framework comprising 6. In addition, the conversion of imidazolones to α,β-unsaturated hydantoins is outlined and represents a new approach to these heterocyclic systems.
Synthesis of slagenins A, B, and C.
Barrios Sosa,Yakushijin,Horne
, p. 3443 - 3444 (2000)
[structure: see text] A short synthesis of the marine sponge metabolites slagenins A (1), B (2), and C (3) is described. The synthetic route features the preparation of beta-hydroxyimidazolone 4 from ornithine and its subsequent oxidative cyclization to the slagenin core.
