308287-86-7

Upstream product

• 175844-64-1 (+)-(1'S,3'R)-3-(3'-acetylamino-2',2'-dimethylcyclobutyl)propanoic acid 
• 865799-07-1 (-)-(1'S,3'S)-2-(3'-acetamido-2',2'-dimethylcyclobutyl)acetic acid 
• 865799-14-0 (1S,3S)-methyl (3-acetamido-2,2-dimethylcyclobutyl)acetate 
• 1379185-80-4 methyl 3-amino-2,2-dimethylcyclobutanecarboxylate 
• 78685-51-5 2,2-dimethyl-3-oxo-cyclobutanecarboxylic acid methyl ester 
• 64396-97-0 (+)-cis-pinonic acid 
• 865799-08-2 (1S,3S)-N-[3-(2,2-diphenyl-2-hydroxyethyl)-2,2-dimethylcyclobutyl]acetamide 
• 865799-10-6 (1S,3S)-N-[3-(2,2-diphenylethenyl)-2,2-dimethylcyclobutyl]acetamide 
• 865799-11-7 (1R,3S)-3-acetamido-2,2-dimethylcyclobutane-carboxylic acid 
• 865799-13-9 (1S,3R)-N-(3-hydroxymethyl-2,2-dimethylcyclobutyl)acetamide 
• 865799-12-8 (1R,3S)-3-amino-2,2-dimethylcyclobutanecarboxylic acid 
• 308287-84-5 Methyl (1S,3R)-(+)-3-acetamido-2,2-dimethylcyclobutanecarboxylate 
• 308287-83-4 (1S,3R)-(+)-3-(2-Acetamido)-2,2-dimethylcyclobutanecarboxylic acid 
• 308287-82-3 (1R,3S)-(+)-N-(3-Ethenyl-2,2-dimethylcyclobutyl)acetamide 

Relevant academic research and scientific papers

SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.

Synthesis of enantiopure cyclobutane amino acids and amino alcohols

(-)-(1R,3S)-3-Amino-2,2-dimethylcyclobutanecarboxylic acid and (+)-(1R,3S)-3-amino-2,2-dimethylcyclobutylmethanol, which can be used to prepare enantiopure oligopeptides and cyclobutane-based carbocyclic nucleosides, were synthesized from (+)-(1R)-α-pinen

Synthesis of (1R, 3R)-3-[2-(aminoethyl)-2,2-dimethylcyclobutyl]methanol and (1S,3R)-(3-amino-2,2-dimethylcyclobutyl)methanol from (+)-nopinone

The title amino alcohols 6 and 7, which are of interest as intermediates in the synthesis of carbocyclic analogs of nucleosides, were synthesized from (+)-nopinone (8). Ring opening of α-isonitrosonopinone leads to a cyanoester which can be directly reduced to 6. Alternatively, a longer route from the lactam 12, one of the Beckmann rearrangement products of 8, leads also to 6, in a higher overall yield. Besides this the isomeric lactam 13 was transformed, upon hydrolytic opening, oxidative degradation of the lateral chain and reduction, into 7.