78685-51-5Relevant academic research and scientific papers
Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005
Bahmanyar, Sogole,Bennett, Brydon,Blease, Kate,Burnett, Kelven,Cashion, Dan,Cathers, Brian E.,Celeridad, Maria,Chan, Henry,Correa, Matthew,Delgado, Mercedes,Hansen, Joshua,Harris, Roy,Hegde, Sayee,Huang, Dehua,Hur, Eun Mi,Khambatta, Godrej,Khattri, Roli,Kulkarni, Ashutosh,Lebrun, Laurie,Leftheris, Katerina,Liu, Zheng,Morrison, Lisa,Mortensen, Deborah S.,Muir, Jeffrey,Norris, Stephen,Papa, Patrick,Parnes, Jason,Plantevin-Krenitsky, Veronique,Ringheim, Garth,Sapienza, John,Torres, Eduardo,Whitefield, Brandon
supporting information, p. 11886 - 11903 (2021/09/03)
The PKC-θ isoform of protein kinase C is selectively expressed in T lymphocytes and plays an important role in the T cell antigen receptor (TCR)-triggered activation of mature T cells, T cell proliferation, and the subsequent release of cytokines such as
HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
-
Page/Page column 79, (2019/01/17)
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
-
Paragraph 0206; 0256, (2015/07/02)
Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.
A Practical synthesis of 3-Acyl cyclobutanones by [2 〈 2] annulation. Mechanism and utility of the zn(II)-Catalyzed condensation of r-Chloroenamines with electron-deficient alkenes
O'Brien, Jeannette M.,Kingsbury, Jason S.
experimental part, p. 1662 - 1672 (2011/05/12)
New conditions for the conversion of simple tertiary amides to R-chloroenamines and their use in Zn(II)-catalyzed cycloaddition reactions with commercial α,β-unsaturated carbonyl compounds allows rapid, regiocontrolled access to 3-acyl cyclobutanones. Rea
