308362-58-5

Upstream product

• 83265-56-9 2-amino-5-(trifluoromethoxy)benzoic acid 
• 871978-26-6 (R)-3-(2-(2-amino-5-trifluoromethoxybenzoylamino)acetamide)pyrrolidone nitric acid salt 
• 850140-83-9 (R)-3-[2-(2-Amino-5-trifluoromethoxybenzamido)acetamido]-1-benzylpyrrolidine hydrochloride 
• 850140-90-8 (R)-3-[2-(2-Amino-5-trifluoromethoxybenzamido)acetamido]pyrrolidine monoacetate 
• 850140-82-8 (R)-3-[2-(2-t-butoxycarbonylamino-5-trifluoromethoxybenzamide)acetamide]-1-(6-methylindol-3-ylmethyl)pyprrolidine 

Relevant academic research and scientific papers

METHOD FOR PRODUCING ACETAMIDOPYRROLIDINE DERIVATIVE AND INTERMEDIATE COMPOUND THEREOF

A production method of an acetamidopyrrolidine derivative or a salt thereof comprising the reaction steps represented by the following formula: wherein R1 represents a hydrogen atom or a C1-C6 alkyl group; R13, R14, R15 and R16 each represent independentl

PROCESS FOR PRODUCING AMINOPYRROLIDINE DERIVATIVE AND INTERMEDIATE COMPOUND

There is provided an industrial production method of an aminopyrrolidine derivative having chemokine receptor antagonist activity represented by the following formula, a synthetic intermediate thereof and a production method thereof: wherein R11 is H, C1-C6 alkyl or C2-C7 alkanoyl; R12, R14, R15, R16 and R17 are H, halogen, optionally halogenated C1-C6 alkyl, optionally halogenated C1-C6 alkoxy, hydroxyl or C2-C7 alkoxycarbonyl; R23, R24, R25 and R26 are H, halogen, optionally halogenated C1-C6 alkyl, optionally halogenated C1-C6 alkoxy or hydroxyl; and R3 is H or C1-C6 alkyl.

CRYSTAL OF AMINOPYRROLIDINE DERIVATIVE AND PRODUCTION METHOD THEREOF

Two crystal forms of (R)-3-[2-(2-amino-5-trifluoromethoxybenzamido) acetamido]-1-(6-methylindol-3-ylmethyl)pyrrolidine which exhibit specific X-ray powder diffraction patterns or infrared absorption spectra, amorphous form thereof, a pharmaceutical compos

METHOD FOR PRODUCING AMINOPYRROLIDINE DERIVATIVE

PROBLEM TO BE SOLVED: To provide a method for simply and industrially producing a chemokine receptor antagonist. SOLUTION: The present invention relates to a method for producing aminopyrrolidine derivatives represented by formulas (wherein R11 is hydrogen atom, a 1-6C alkyl group or a 2-7C alkanoyl group; R12, R14, R15, R16 and R17 are each independently hydrogen atom, a halogen atom, a 1-6C alkyl group which is substituted with a halogen atom, a 1-6C alkoxyl group which is substituted with a halogen atom, a hydroxy group or a 2-7C alkoxycarbonyl group; R1 and R2 are each independently hydrogen atom or a protective group of an amino group in which R1 and R2 together may form a ring structure; R23, R24, R25 and R26 are each independently hydrogen atom, a halogen atom, a 1-6C alkyl group which may be substituted with a halogen atom, a 1-6C alkoxyl group which may be substituted with a halogen atom or a hydroxy group; R3 is a hydrogen atom or a 1-6C alkyl group) or their salts.

METHOD FOR PRODUCING ACETAMIDOPYRROLIDINE DERIVATIVE AND INTERMEDIATE COMPOUND THEREOF

Disclosed is a method for producing an acetamidopyrrolidine derivative or a salt thereof comprising a reaction process expressed by the following formulae. Formulae In the formulae, R1 represents a hydrogen atom or a C1-C6 alkyl group; R13, R14, R15 and R16 independently represent a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkoxy group, a hydroxy group, a C1-C6 halogenated alkyl group or a C1-C6 halogenated alkoxy group; and R21 represents an ester-protecting group.