308364-83-2Relevant academic research and scientific papers
Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx(TM))
Nicoll-Griffith, Deborah A.,Yergey, James A.,Trimble, Laird A.,Silva, Jose M.,Li, Chun,Chauret, Nathalie,Gauthier, Jacques Yves,Grimm, Erich,Leger, Serge,Roy, Patrick,Therien, Michel,Wang, Zhaoyin,Prasit, Peppi,Zamboni, Robert,Young, Robert N.,Brideau, Christine,Chan, Chi-Chung,Mancini, Joseph,Riendeau, Denis
, p. 2683 - 2686 (2007/10/03)
Metabolites of the COX-2 inhibitor rofecoxib (MK-0966, Vioxx(TM)) were prepared by synthetic or biosynthetic methods. Metabolites include products of oxidation, glucuronidation, reduction and hydrolytic ring opening. Based on an in vitro whole blood assay
