185147-17-5

Basic information

• Product Name: 5-Hydroxy Vioxx
• Synonyms: 5-Hydroxy Vioxx;5-Hydroxy-4-[4-(Methylsulfonyl)phenyl]-3-phenyl-
• CAS NO: 185147-17-5
• Molecular Formula: C₁₇H₁₄O₅S
• Molecular Weight: 330.35506
• Product Categories: Aromatics;Heterocycles;Metabolites & Impurities;Sulfur & Selenium Compounds;Aromatics, Heterocycles, Metabolites & Impurities, Sulfur & Selenium Compounds
• Mol File: 185147-17-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 598.9°Cat760mmHg
• Flash Point: 316°C
• Appearance: /
• Density: 1.365g/cm³
• Vapor Pressure: 3.44E-15mmHg at 25°C
• Refractive Index: 1.612
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
• CAS DataBase Reference: 5-Hydroxy Vioxx(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Hydroxy Vioxx(185147-17-5)
• EPA Substance Registry System: 5-Hydroxy Vioxx(185147-17-5)

Safety Data

• Hazardous Substances Data: 185147-17-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 185147-17-5 differently. You can refer to the following data:
1. As a metabolite of Vioxx, 5-Hydroxy Vioxx was highly dependent on the subcellular fraction and the redox system used.
2. A metabolite of Vioxx. The biotransformation of Rofecoxib (Vioxx) was highly dependent on the subcellular fraction and the redox system used.

InChI:InChI=1/C17H16O5S/c1-23(20,21)13-9-7-12(8-10-13)15-14(16(18)22-17(15)19)11-5-3-2-4-6-11/h2-10,14-15,17,19H,1H3

Upstream product

• 162011-90-7 rofecoxib 
• 1778-09-2 4-(Methylthio)acetophenone 
• 42445-46-5 2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone 
• 185147-16-4 Benzoic acid, 3-(4-(methylsulfonyl)phenyl)-5-oxo-4-phenyl-2,5-dihydrofuran-2-yl ester 
• 691005-66-0 (+/-)-5-bromo-4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one 

Downstream Products

• 213764-15-9 5-(4-methylsulfonyl)phenyl-4-phenyl-2H-pyridazin-3-one 
• 213763-81-6 2-cyclopropylmethyl-5-(4-methylsulfonyl)phenyl-4-phenyl-2H-pyridazin-3-one 
• 308364-83-2 5-Hydroxyrofecoxib glucuronide 

Relevant articles and documents

PURIFIED FORMS OF ROFECOXIB, METHODS OF MANUFACTURE AND USE

The subject matter disclosed herein relates to rofecoxib, also known as TRM-201 or RXB-201, its method of manufacture, and use. In certain aspects, the highly pure or substantially pure rofecoxib as provided herein has a favorable purity profile and is the active ingredient in a pharmaceutical composition that is administered to treat or prevent a number of conditions, including pain associated with a condition caused by a bleeding disorder.

Pyridazinones as selective cyclooxygenase-2 inhibitors

Pyridazinone was found to be an excellent core template for selective COX-2 inhibitors. Two potent, selective and orally active COX-2 inhibitors, which were highly efficacious in rat paw edema and rat pyresis models, have been obtained.

Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors

The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.