30863-82-2Relevant articles and documents
Pd/PTABS: Low-Temperature Thioetherification of Chloro(hetero)arenes
Bandaru, Siva Sankar Murthy,Bhilare, Shatrughn,Cardozo, Jesvita,Chrysochos, Nicolas,Schulzke, Carola,Sanghvi, Yogesh S.,Gunturu, Krishna Chaitanya,Kapdi, Anant R.
, p. 8921 - 8940 (2019/07/08)
The thioetherification of heteroaryl chlorides is an essential synthetic methodology that provides access to bioactive drugs and agrochemicals. Due to their (actual or potential) industrial importance, the development of efficient and low-temperature protocols for accessing these compounds is a requirement for economic and ecologic reasons. A particular highly effective catalytic protocol using the Pd/PTABS system at only 50 °C was developed accordingly. The coupling between chloroheteroarenes and a variety of less reactive arylthiols and alkylthiols was carried out with a high efficiency. Heteroarenes of commercial relevance such as purines and pyrimidines were also found to be useful substrates for the reported transformation. The commercial drug Imuran (azathioprine) was synthesized as an example, and its preparation could be optimized. DFT studies were performed to understand the electronic effects of the tested ligands on the catalytic reaction.
Janus head type lone pair-π-lone pair and S?F?S interactions in retaining hexafluorobenzene
Mehrotra, Sonam,Angamuthu, Raja
, p. 4438 - 4444 (2016/07/06)
A series of eight tris-arylthiotriazines were synthesized to study the lone pair-π interaction between the triazine ring centroid of these molecules and halogenated solvents. All the eight compounds were characterized using 1H and 13C NMR spectroscopy and single crystal X-ray diffraction techniques. All these compounds show interesting structural properties in the solid state. Unprecedented Janus head type lp?π?lp and S?F?S interactions were observed between one of the tris-arylthiotriazines and hexafluorobenzene.
THE OXIDATION OF TRITHIOCYANURIC ACID AND OF ITS N- AND S-ESTERS
Tripolt, Robert,Nachbaur, Edgar
, p. 173 - 176 (2007/10/02)
The reaction of trithiocyanuric acid 1 with 3 equivalents of 2-benzenesulfonyl-3-phenyl-oxaziridine affords the highly reactive 1,3,5-triazine-2,4,6-trisulfenic acid 3, which is trapped by reaction with diazomethane to give the trimethylester of 3.Additionally the reactions of trithioisocyanurates and trithiocyanurates with meta-chloroperbenzoic acid (mCPBA), oxaziridine, dimethyldioxirane and chlorine are studied.