30866-28-5Relevant academic research and scientific papers
The reaction of ethyl 2-oxo-2H-chromene-3-carboxylate with hydrazine hydrate
Abdel-Aziz, Hatem A.,Elsaman, Tilal,Attia, Mohamed I.,Alanazi, Amer M.
, p. 2084 - 2095 (2013/04/23)
Although salicylaldehyde azine (3) was reported in 1985 as the single product of the reaction of ethyl 2-oxo-2H-chromene-3-carboxylate (1) with hydrazine hydrate, we identified another main reaction product, besides 3, which was identified as malono-hydrazide (4). In the last two decades, however, some articles have claimed that this reaction afforded exclusively hydrazide 2 and they have reported the use of this hydrazide 2 as a precursor in the syntheses of several heterocyclic compounds and hydrazones 6. We reported herein a study of the formation of 2 and a facile route for the synthesis of the target compounds N'-arylidene-2-oxo-2H-chromene-3-carbohydrazides 6a-f.
